Featured Research

from universities, journals, and other organizations

New malaria vaccine depends on … mosquito bites?

Date:
February 15, 2011
Source:
Tulane University
Summary:
The same menace that spreads malaria -- the mosquito bite -- could help wipe out the deadly disease, according to researchers working on a new vaccine.

Nirbhay Kumar, professor of tropical medicine at Tulane University, is working on a vaccine that aims to wipe out malaria using the same menace that spreads it -- the mosquito bite.
Credit: Image courtesy of Tulane University

The same menace that spreads malaria -- the mosquito bite -- could help wipe out the deadly disease, according to researchers working on a new vaccine at Tulane University.

The PATH Malaria Vaccine Initiative (MVI), established in 1999 through a grant from the Bill & Melinda Gates Foundation, announced February 15 a collaboration with Tulane University School of Public Health and Tropical Medicine and India's Gennova Biopharmaceuticals Ltd. to produce and test a novel vaccine that aims to inoculate mosquitoes when they bite people.

The vaccine would work by triggering an immune response in people so they produce antibodies that target a protein the malaria parasite needs to reproduce within a mosquito.

Malaria, which kills nearly 800,000 people every year worldwide, is caused by a microscopic parasite that alternates between human and mosquito hosts at various stages of its lifecycle. Once a mosquito bites a vaccinated person, the antibodies would neutralize the protein essential for malaria parasite's reproduction, effectively blocking the parasite's -- and the mosquito's -- ability to infect others.

The vaccine relies on a protein -- known as Pfs48/45 -- which is very difficult to synthetically produce, says Nirbhay Kumar, professor of tropical medicine at Tulane.

"With MVI's support we can now work with Gennova to produce sufficient quantity of the protein and develop a variety of vaccine formulations that can be tested in animals to determine which one give us the strongest immune response," Kumar says.

Such transmission blocking vaccines, though not yet widely tested in humans, are attracting widespread interest due to their potential to be used in conjunction with more traditional malaria vaccines and other interventions -- such as malaria drugs and bed nets -- to make gradual elimination and even eradication of the disease a reality.

"We're investing in developing transmission blocking malaria vaccines to support two long-term goals: introducing an 80 percent efficacious malaria vaccine by the year 2025 and eventually eradicating malaria altogether," says Dr. Christian Loucq, director of MVI. "A vaccine that breaks the cycle of malaria transmission will be important to our success."


Story Source:

The above story is based on materials provided by Tulane University. Note: Materials may be edited for content and length.


Cite This Page:

Tulane University. "New malaria vaccine depends on … mosquito bites?." ScienceDaily. ScienceDaily, 15 February 2011. <www.sciencedaily.com/releases/2011/02/110215132212.htm>.
Tulane University. (2011, February 15). New malaria vaccine depends on … mosquito bites?. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2011/02/110215132212.htm
Tulane University. "New malaria vaccine depends on … mosquito bites?." ScienceDaily. www.sciencedaily.com/releases/2011/02/110215132212.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins