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Promise of genomics research needs a realistic view, experts urge

Date:
February 18, 2011
Source:
Indiana University School of Medicine
Summary:
Unrealistic expectations about genomic medicine have created a "bubble" that needs deflating before it puts the field's long term benefits at risk, according to a group of policy experts.

Unrealistic expectations about genomic medicine have created a "bubble" that needs deflating before it puts the field's long term benefits at risk, four policy experts write in the current issue of the journal Science.

Ten years after the deciphering of the human genetic code was accompanied by over-hyped promises of medical breakthroughs, it may be time to reevaluate funding priorities to better understand how to change behaviors and reap the health benefits that would result.

In addition, the authors say, scientists need to foster more realistic understanding about how scientific research works "by making responsible claims and by advocating that reporters and editors do the same."

"Our fear is that if we are uncritical and naοve in our enthusiasm for these exciting technologies we risk both diversion of precious resources and premature implementation, which could hurt patients, as well as produce a backlash, which will hurt our field," said lead author medical geneticist James P. Evans, M.D., Ph.D., Bryson Distinguished Professor of Genetics and Medicine at the University of North Carolina at Chapel Hill and the UNC Lineberger Comprehensive Cancer Center.

"We feel it's time to assess the progress made towards achieving the hoped-for benefits from genomic science," said Eric M. Meslin, Ph.D., director of the Indiana University Center for Bioethics and one of the commentary's co-authors. "While we remain excited about the science, we also think the time has come to ask why the pace of progress has been slower than expected and what science and society might do about it."

The commentary appears in the Feb. 18, 2011, issue of the journal Science. Co-authors with Evans and Meslin are Theresa M. Marteau, Ph.D., F.Med.Sci., professor of health psychology, Kings College, London, UK; and Timothy Caulfield, LL.M., F.R.S.C., Canada Research Chair in Health Law & Policy, at the University of Alberta.

The authors agree that progress in genomic research has been "breathtaking," noting, as an example, that routine whole-genome sequencing may soon be a reality. But, they caution, the considerable promise of genomics must be evaluated through a realistic lens. After all, while advances are being made in personalized medicine through the tools of pharmacogenetics, "the most powerful predictor of drug efficacy is whether a patient takes the drug."

  • In many diseases a large number of genes play a role, making meaningful predictions difficult both for individuals and in public health.
  • There's little evidence that advising people they are at genetically increased risk for disease has significant impact on their behavior, while telling others they are at less risk can promote bad behaviors.
  • Translating scientific findings into patient care is an "inherently messy" process, as demonstrated by hormone replacement therapy and other "ideas that didn't pan out when scrutinized through the lens of evidence-based medicine."

Even so, the authors write, the benefits of genomic research will come, resulting in understanding the mechanisms of disease, improved diagnostics and better therapies -- but those benefits will be decades in the making.

The authors offer their short list of recommendations, including "a reappraisal of the apportioning of research funds" and efforts to help more people understand that progress in science is incremental.

In addition, they recommend maintaining focus on developing high quality evidence before moving new ideas into patient care, while also developing new ways to assess clinical evidence so promising new treatments are not delayed.

"We believe that the current age of genomics will provide great benefits to human health … Ours is not a call to gut existing research or too-rigidly tie funding to degree of disease burden," the authors assert.

"The pursuit of our common goal -- improved human health -- demands that we take a hard look at disease causation and order our priorities accordingly."


Story Source:

The above story is based on materials provided by Indiana University School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. James P. Evans, Eric M. Meslin, Theresa M. Marteau, Timothy Caulfield. Deflating the Genomic Bubble. Science, 2011; 331 (6019): 861-862 DOI: 10.1126/science.1198039

Cite This Page:

Indiana University School of Medicine. "Promise of genomics research needs a realistic view, experts urge." ScienceDaily. ScienceDaily, 18 February 2011. <www.sciencedaily.com/releases/2011/02/110217141309.htm>.
Indiana University School of Medicine. (2011, February 18). Promise of genomics research needs a realistic view, experts urge. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2011/02/110217141309.htm
Indiana University School of Medicine. "Promise of genomics research needs a realistic view, experts urge." ScienceDaily. www.sciencedaily.com/releases/2011/02/110217141309.htm (accessed April 20, 2014).

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