Featured Research

from universities, journals, and other organizations

Screening mammograms catch second breast cancers early, study finds

Date:
February 22, 2011
Source:
Group Health Research Institute
Summary:
More women are surviving longer after having early-stage breast cancer, but they are at risk of developing breast cancer again. Annual screening mammography has long been standard for these women, but only scant evidence on screening outcomes supported this practice. In the Feb. 23, 2011 JAMA, the most comprehensive relevant study to date shows yearly mammograms do detect second breast cancers early. The Breast Cancer Surveillance Consortium study examined 12 years of information.

More women are surviving longer after having early-stage breast cancer, but they are at risk of developing breast cancer again: a recurrence or a new cancer, in either breast. Annual screening (a.k.a. "surveillance") mammography has long been standard for these women, but only scant evidence on screening outcomes supported this practice. In the Feb. 23 Journal of the American Medical Association, the most comprehensive relevant study to date shows yearly mammograms do detect second breast cancers early.

The Breast Cancer Surveillance Consortium (BCSC) study examined 12 years of information from 58,870 screening mammograms in 19,078 women who had had early-stage breast cancer -- and an equal number of screening mammograms in 55,315 women who had no such history and were matched for breast density, age, BCSC registry, and year of mammography.

With her BCSC colleagues, Nehmat Houssami, MBBS, PhD, an associate professor at the University of Sydney's School of Public Health and Sydney Medical School and a physician at the Royal Hospital for Women, in Australia, found that women with a personal history of breast cancer had double the cancer rates as those with no such history. Women who had had breast cancer had 655 second cancers within a year of screening mammography, and those with no prior breast cancer had 342 cancers, with cancer rates of 10.5 vs. 5.8 per 1,000 screens, respectively.

"The comprehensive data from the BCSC made it possible for us to carefully examine the outcomes of screening for both the previously affected (conserved) breast, as well as the opposite breast, at a population level," Dr Houssami said. "This is the first study in the world, to our knowledge, to provide a complete picture of the expected outcomes of mammography screening for women with a personal history of breast cancer."

"Mammography was effective at finding cancers early in women who had had cancer, but not quite as effective as in those who had not," Dr. Houssami said, "We found that both false positives and 'interval cancers' were higher, and mammography was not as sensitive at detecting invasive breast cancer, in women with a personal history of breast cancer." False positives mean that a mammogram suggests a breast cancer may be present, but after further testing it turns out not to be. Interval cancers are breast cancers that were not detected on screening mammography and are found between mammography screens, prompted by either breast symptoms or additional testing.

"Because of the risk of interval cancers, it's important that women seek medical care for any breast changes or concerns between mammograms," said Dr. Houssami's collaborator Diana Miglioretti, PhD, a senior investigator at Group Health Research Institute. "The good news is that most of the breast cancers detected in breast cancer survivors between mammography screens were early stage."

Interval-cancer rates were particularly high in women who were younger than 50, had extremely dense breasts, or received breast-conserving treatment (lumpectomy) without radiotherapy for their first cancer. "Our results suggest that we should consider more tailored screening strategies in these women, such as additional or alternate screening modalities in some groups -- but this needs further research," Dr. Miglioretti said.

The National Cancer Institute-funded BCSC cooperative agreement, and Australia's National Health and Medical Research Council funding of the Screening and Test Evaluation Program, supported this research. Data collection was supported in part by several U.S. state public health departments and cancer registries.

Collaborating with Drs. Houssami and Miglioretti were Diana S.M. Buist, PhD, MPH, and Linn A. Abraham, MS, of Group Health Research Institute; Edward A. Sickles, MD, and Karla Kerlikowske, MD, of the University of California, San Francisco; Berta M. Geller, EdD, of the University of Vermont, in Burlington; Hyman B. Muss, MD, of the University of North Carolina, in Chapel Hill; and Les Irwig, MBBCh, PhD, of the University of Sydney, in Australia.


Story Source:

The above story is based on materials provided by Group Health Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nehmat Houssami, Linn A. Abraham, Diana L. Miglioretti, Edward A. Sickles, Karla Kerlikowske, Diana S. M. Buist, Berta M. Geller, Hyman B. Muss, Les Irwig. Accuracy and Outcomes of Screening Mammography in Women With a Personal History of Early-Stage Breast Cancer. JAMA, 2011; 305 (8): 790-799 DOI: 10.1001/jama.2011.188

Cite This Page:

Group Health Research Institute. "Screening mammograms catch second breast cancers early, study finds." ScienceDaily. ScienceDaily, 22 February 2011. <www.sciencedaily.com/releases/2011/02/110222162316.htm>.
Group Health Research Institute. (2011, February 22). Screening mammograms catch second breast cancers early, study finds. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2011/02/110222162316.htm
Group Health Research Institute. "Screening mammograms catch second breast cancers early, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/02/110222162316.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins