Featured Research

from universities, journals, and other organizations

Whole fresh blood for transfusions may have a longer shelf life than now assumed

Date:
February 24, 2011
Source:
Children's Hospital of Philadelphia
Summary:
In a finding that may potentially improve survival from war injuries and disasters, laboratory researchers report that refrigerated whole blood may have a shelf life well beyond the current standard of 24 to 48 hours. The researchers found that whole blood retains its clotting properties at least 11 days under standard refrigeration. If confirmed in clinical studies, the finding could lead to improved survival for patients requiring massive transfusions.

In a finding that may potentially improve survival from war injuries and disasters, laboratory researchers report that refrigerated whole blood may have a shelf life well beyond the current standard of 24 to 48 hours.

"We have found that whole blood retains its clotting properties at least 11 days under standard refrigeration," said the study leader, David Jobes, M.D., a cardiothoracic anesthesiologist in the Cardiac Center at The Children's Hospital of Philadelphia. "If this lab discovery can be confirmed in human subjects, it may lead to a change in clinical practice, and possibly to improved survival for massively transfused patients."

The study appears in the January 2011 issue of the journal Transfusion.

The majority of patients receiving blood transfusions only require specific components of whole blood, such as red blood cells, plasma and platelets. However, whole blood may be preferable in specific situations such as infant heart surgery and combat casualties.

The definition of freshness of whole blood with respect to its clotting properties has not been systematically studied. The current practice at The Children's Hospital of Philadelphia assumes a fresh whole blood shelf life of 48 hours when refrigerated. After that point, the red blood cells may be recovered from the whole blood, but the other components, such as plasma and platelets must be discarded. "In any case, postponed surgeries currently waste resources," said Jobes.

Based on reports from military clinicians and on the authors' own observations in pediatric cardiac surgery, Jobes and colleagues did a laboratory study to measure the duration of blood coagulation properties in refrigerated whole blood.

The researchers used 21 units of whole blood from healthy volunteer donors, performing the study in the hematology and coagulation laboratory led by Long Zheng, M.D., Ph.D., in the clinical laboratory at The Children's Hospital of Philadelphia. They found that thromboelastography (TEG) and platelet aggregation levels, which measure the efficiency of blood coagulation, remain normal at least 11 days under standard refrigerated conditions.

If these results hold up under follow-up studies in human subjects, a change in current practice could increase the availability and usefulness of whole blood, especially in military or disaster relief situations, and in remote locations. "Trauma patients could potentially benefit, as well as others needing a large volume of blood replacement, such as patients undergoing liver transplant or children who need craniofacial reconstruction," said Jobes.

Furthermore, Jobes added, more efficient use of donated whole blood, besides reducing wastage, could lower the number of donors needed, and thus increase safety by reducing the risks of inadvertently transmitting blood borne viruses.

In all, said Jobes, "Our results strongly suggest that clinical trials should proceed to test the value of whole blood beyond a 48-hour period."

Grants from the Cardiac Center and the Departmental Fund of Pathology and Laboratory Medicine, both at The Children's Hospital of Philadelphia, supported this study.


Story Source:

The above story is based on materials provided by Children's Hospital of Philadelphia. Note: Materials may be edited for content and length.


Journal Reference:

  1. David Jobes, Yanika Wolfe, Daniel O'Neill, Jennifer Calder, Lisa Jones, Deborah Sesok-Pizzini, X. Long Zheng. Toward a definition of “fresh” whole blood: an in vitro characterization of coagulation properties in refrigerated whole blood for transfusion. Transfusion, 2011; 51 (1): 43 DOI: 10.1111/j.1537-2995.2010.02772.x

Cite This Page:

Children's Hospital of Philadelphia. "Whole fresh blood for transfusions may have a longer shelf life than now assumed." ScienceDaily. ScienceDaily, 24 February 2011. <www.sciencedaily.com/releases/2011/02/110223125017.htm>.
Children's Hospital of Philadelphia. (2011, February 24). Whole fresh blood for transfusions may have a longer shelf life than now assumed. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2011/02/110223125017.htm
Children's Hospital of Philadelphia. "Whole fresh blood for transfusions may have a longer shelf life than now assumed." ScienceDaily. www.sciencedaily.com/releases/2011/02/110223125017.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Predicting Heart Transplant Rejection With a Blood Test

Predicting Heart Transplant Rejection With a Blood Test

Ivanhoe (Aug. 27, 2014) Now a new approach to rejection of donor organs could change the way doctors predict transplant rejection…without expensive, invasive procedures. Video provided by Ivanhoe
Powered by NewsLook.com
Better Braces That Vibrate

Better Braces That Vibrate

Ivanhoe (Aug. 27, 2014) The length of time you have to keep your braces on could be cut in half thanks to a new device that speeds up the process. Video provided by Ivanhoe
Powered by NewsLook.com
Smartphone App Tracks Your Heart Rate

Smartphone App Tracks Your Heart Rate

Ivanhoe (Aug. 27, 2014) A new app that can track your heart rate 24/7 is available for download in your app store and its convenience could save your life. Video provided by Ivanhoe
Powered by NewsLook.com
Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins