Featured Research

from universities, journals, and other organizations

New insights into tendon injury

Date:
March 1, 2011
Source:
University of Manchester
Summary:
Scientists have discovered how tendons -- the fibrous tissue that connects muscle to bone -- become damaged through injury or the aging process in what could lead to new treatments for people with tendon problems.

Scientists have discovered how tendons -- the fibrous tissue that connects muscle to bone -- become damaged through injury or the aging process in what could lead to new treatments for people with tendon problems.

Related Articles


The University of Manchester team, working with colleagues at Glasgow University, have been investigating 'adhesions', which are a build up of unwanted fibrous tissue on internal organs that have been damaged as a result of surgery or injury.

Adhesions cause organs to stick together and are extremely painful and distressing for patients, who often have to undergo surgery and rehabilitation. The estimated cost of adhesions to the NHS is 100 million each year.

In this study, published in the journal PLoS ONE, the researchers wanted to understand how tendon adhesions form, so examined the surface of healthy tendons and discovered that they are covered by a thin layer of skin.

"Tendons attach our muscles to bone and are essential for movement," said lead researcher Professor Karl Kadler, from the Wellcome Trust Centre for Cell Matrix Research in Manchester's Faculty of Life Sciences.

"In order to do this, tendons need to glide freely but when an adhesion forms the tendon can no longer travel over the bone, which causes pain, stiffness and reduced movement.

"We reasoned that the surface of tendons must contain a special cell that stops adhesions from forming in healthy people. We discovered that the tendon is actually covered by a thin layer of epithelial cells, which are usually found in skin.

"Undamaged tendons do not form adhesions but when the tendon 'skin' is damaged, the cells inside the tendon form an unwanted adhesion which begins to stick to nearby tissues."

The team were able to show that mice with defective cells at the surface of their tendons appeared to have difficulty walking and spontaneously develop tendon adhesions, even without surgery or injury.

Dr Susan Taylor, from The University of Manchester and co-author on the paper, added: "This study of tendon adhesions shows that the integrity of the surface of a tissue is critical in preventing adhesions. Furthermore, the discovery of this completely new layer of tendon cells changes the way we are thinking about how tendons are made during embryonic development and maintained in adulthood. Future research is aimed at finding ways of protecting the tendon epithelium in older people and in athletes."


Story Source:

The above story is based on materials provided by University of Manchester. Note: Materials may be edited for content and length.


Journal Reference:

  1. Susan H. Taylor, Sarah Al-Youha, Tom Van Agtmael, Yinhui Lu, Jason Wong, Duncan A. McGrouther, Karl E. Kadler. Tendon Is Covered by a Basement Membrane Epithelium That Is Required for Cell Retention and the Prevention of Adhesion Formation. PLoS ONE, 2011; 6 (1): e16337 DOI: 10.1371/journal.pone.0016337

Cite This Page:

University of Manchester. "New insights into tendon injury." ScienceDaily. ScienceDaily, 1 March 2011. <www.sciencedaily.com/releases/2011/03/110301091450.htm>.
University of Manchester. (2011, March 1). New insights into tendon injury. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2011/03/110301091450.htm
University of Manchester. "New insights into tendon injury." ScienceDaily. www.sciencedaily.com/releases/2011/03/110301091450.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com
British Navy Ship Arrives in Sierra Leone With Ebola Aid

British Navy Ship Arrives in Sierra Leone With Ebola Aid

AFP (Oct. 30, 2014) The British ship RFA ARGUS arrived in Sierra Leone to deliver supplies and equipment to help the fight against Ebola. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins