Featured Research

from universities, journals, and other organizations

Susceptibility factor for bipolar disorder identified

Date:
March 3, 2011
Source:
Cell Press
Summary:
A new study provides fascinating insight into the genetic basis of bipolar disorder, a highly heritable mood disorder characterized by recurrent episodes of mania and depression. The research identifies a previously unrecognized susceptibility factor for bipolar disorder.

A new study provides fascinating insight into the genetic basis of bipolar disorder, a highly heritable mood disorder characterized by recurrent episodes of mania and depression. The research, published online February 24 in the American Journal of Human Genetics, identifies a previously unrecognized susceptibility factor for bipolar disorder.

Genome-wide association studies (GWAS) provide a way to systematically sort through all the DNA of many individuals in order to identify genetic variations associated with a particular disease. However, thus far these studies have not been as successful in bipolar disorder as they have been for several other common diseases, such as type II diabetes, Crohn disease, and schizophrenia. Dr. Sven Cichon, from the University of Bonn in Germany, together with his colleagues Dr. Markus M. Nöthen (University of Bonn) and Dr. Marcella Rietschel (Central Institute of Mental Health, Mannheim), led a GWAS and a critical two-step follow-up study of samples from a great number of clinically well-characterized European, American, and Australian individuals with bipolar disorder.

Dr. Cichon and colleagues found that genetic variation in the gene neurocan (NCAN) showed a significant association with bipolar disorder in thousands of patients. Importantly, in a follow up study, these findings were replicated in tens of thousands of individual samples of bipolar disorder. The researchers went on to show that the mouse version of this gene, which is written Ncan and is thought to be involved in neuronal adhesion and migration, is strongly expressed in brain areas associated with cognition and the regulation of emotions.

Although mice without functional Ncan did not exhibit obvious defects in brain structure or basic cell communication, there did appear to be some perturbation in mechanisms associated with learning and memory, mechanisms that have been associated with the cognitive deficits observed in bipolar disorder. However, the authors caution that Ncan-deficient mice need to be re-examined for more subtle brain changes and behavioral abnormalities.

"Our results provide strong evidence that genetic variation in the gene NCAN is a common risk factor for bipolar disorder," concludes Dr. Cichon. "Further work is needed now to learn more about the biological processes that NCAN is involved in and how NCAN variants disturb neuronal processes in patients with bipolar disorder."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sven Cichon, Thomas W. Mühleisen, Franziska A. Degenhardt, Manuel Mattheisen, Xavier Miró, Jana Strohmaier, Michael Steffens, Christian Meesters, Stefan Herms, Moritz Weingarten et al. Genome-wide Association Study Identifies Genetic Variation in Neurocan as a Susceptibility Factor for Bipolar Disorder. The American Journal of Human Genetics, 2011; DOI: 10.1016/j.ajhg.2011.01.017

Cite This Page:

Cell Press. "Susceptibility factor for bipolar disorder identified." ScienceDaily. ScienceDaily, 3 March 2011. <www.sciencedaily.com/releases/2011/03/110303111630.htm>.
Cell Press. (2011, March 3). Susceptibility factor for bipolar disorder identified. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2011/03/110303111630.htm
Cell Press. "Susceptibility factor for bipolar disorder identified." ScienceDaily. www.sciencedaily.com/releases/2011/03/110303111630.htm (accessed August 27, 2014).

Share This




More Mind & Brain News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) — A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com
Distracted Adults: ADHD?

Distracted Adults: ADHD?

Ivanhoe (Aug. 27, 2014) — Most people don’t realize that ADHD isn’t just for kids. It can affect the work as well as personal lives of many adults, and often times they don’t even know they have it. Video provided by Ivanhoe
Powered by NewsLook.com
The Sight and Sounds of Autism

The Sight and Sounds of Autism

Ivanhoe (Aug. 27, 2014) — A new study is explaining why for some people with autism what they see and what they hear is out of sync. Video provided by Ivanhoe
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) — A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins