Featured Research

from universities, journals, and other organizations

Molecular mechanism contributing to neuronal circuit formation found

Date:
April 25, 2011
Source:
Helmholtz Zentrum München - German Research Center for Environmental Health
Summary:
Scientists have discovered how sensory and motor fibers interact during development of neuronal circuits in the limbs: Both types of nerve fibers can guide this process. With this finding, the researchers have made an important contribution to understanding how neural networks are formed during embryonic development and have found a new approach to explaining neurological disorders.

Researchers observed that motor and sensory axons were both able to guide and lead the formation of the spinal nerves of the arms and legs.
Credit: Image courtesy of Helmholtz Zentrum München - German Research Center for Environmental Health

Scientists at Helmholtz Zentrum München have discovered how sensory and motor fibers* interact during development of neuronal circuits in the limbs: Both types of nerve fibers can guide this process. With this finding, the researchers have made an important contribution to understanding how neural networks are formed during embryonic development and have found a new approach to explaining neurological disorders.

Related Articles


During embryonic development, sensory and motor fibers interact to form nerves in the limbs. The research team led by Dr. Andrea Huber Brösamle of the Institute of Developmental Genetics of Helmholtz Zentrum München has now elucidated how this interaction functions at the molecular level: The cell surface receptor neuropilin-1 is present in both sensory and motor nerve fibers and controls their interaction in order to correctly regulate growth.

"We observed that motor and sensory axons were both able to guide and lead the formation of the spinal nerves of the arms and legs," said Rosa-Eva Hüttl and Heidi Söllner, lead authors of the study and doctoral students in Dr. Andrea Huber Brösamle's research group. This finding surprised the authors because it had previously been assumed that the motor axons were always responsible for establishing the correct trajectories. In the same study, the researchers created a model to better elucidate structural changes in human neurodegenerative disorders and following trauma : "Our next goal," said Dr. Huber Brösamle, "is to find out to what extent neuropilin-1 also controls the formation of fiber tracts in the brain."

Note:

*Nerves are bundles of sensory and motor fibers. The sensory fibers transmit physical sensation signs (e.g. pain), while the motor fibers control the contraction and movement of muscles.


Story Source:

The above story is based on materials provided by Helmholtz Zentrum München - German Research Center for Environmental Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rosa-Eva Huettl, Heidi Soellner, Elisa Bianchi, Bennett G. Novitch, Andrea B. Huber. Npn-1 Contributes to Axon-Axon Interactions That Differentially Control Sensory and Motor Innervation of the Limb. PLoS Biology, 2011; 9 (2): e1001020 DOI: 10.1371/journal.pbio.1001020

Cite This Page:

Helmholtz Zentrum München - German Research Center for Environmental Health. "Molecular mechanism contributing to neuronal circuit formation found." ScienceDaily. ScienceDaily, 25 April 2011. <www.sciencedaily.com/releases/2011/03/110307101303.htm>.
Helmholtz Zentrum München - German Research Center for Environmental Health. (2011, April 25). Molecular mechanism contributing to neuronal circuit formation found. ScienceDaily. Retrieved December 17, 2014 from www.sciencedaily.com/releases/2011/03/110307101303.htm
Helmholtz Zentrum München - German Research Center for Environmental Health. "Molecular mechanism contributing to neuronal circuit formation found." ScienceDaily. www.sciencedaily.com/releases/2011/03/110307101303.htm (accessed December 17, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, December 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) — Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) — Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) — According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) — A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins