Featured Research

from universities, journals, and other organizations

Molecular mechanism contributing to neuronal circuit formation found

Date:
April 25, 2011
Source:
Helmholtz Zentrum München - German Research Center for Environmental Health
Summary:
Scientists have discovered how sensory and motor fibers interact during development of neuronal circuits in the limbs: Both types of nerve fibers can guide this process. With this finding, the researchers have made an important contribution to understanding how neural networks are formed during embryonic development and have found a new approach to explaining neurological disorders.

Researchers observed that motor and sensory axons were both able to guide and lead the formation of the spinal nerves of the arms and legs.
Credit: Image courtesy of Helmholtz Zentrum München - German Research Center for Environmental Health

Scientists at Helmholtz Zentrum München have discovered how sensory and motor fibers* interact during development of neuronal circuits in the limbs: Both types of nerve fibers can guide this process. With this finding, the researchers have made an important contribution to understanding how neural networks are formed during embryonic development and have found a new approach to explaining neurological disorders.

During embryonic development, sensory and motor fibers interact to form nerves in the limbs. The research team led by Dr. Andrea Huber Brösamle of the Institute of Developmental Genetics of Helmholtz Zentrum München has now elucidated how this interaction functions at the molecular level: The cell surface receptor neuropilin-1 is present in both sensory and motor nerve fibers and controls their interaction in order to correctly regulate growth.

"We observed that motor and sensory axons were both able to guide and lead the formation of the spinal nerves of the arms and legs," said Rosa-Eva Hüttl and Heidi Söllner, lead authors of the study and doctoral students in Dr. Andrea Huber Brösamle's research group. This finding surprised the authors because it had previously been assumed that the motor axons were always responsible for establishing the correct trajectories. In the same study, the researchers created a model to better elucidate structural changes in human neurodegenerative disorders and following trauma : "Our next goal," said Dr. Huber Brösamle, "is to find out to what extent neuropilin-1 also controls the formation of fiber tracts in the brain."

Note:

*Nerves are bundles of sensory and motor fibers. The sensory fibers transmit physical sensation signs (e.g. pain), while the motor fibers control the contraction and movement of muscles.


Story Source:

The above story is based on materials provided by Helmholtz Zentrum München - German Research Center for Environmental Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rosa-Eva Huettl, Heidi Soellner, Elisa Bianchi, Bennett G. Novitch, Andrea B. Huber. Npn-1 Contributes to Axon-Axon Interactions That Differentially Control Sensory and Motor Innervation of the Limb. PLoS Biology, 2011; 9 (2): e1001020 DOI: 10.1371/journal.pbio.1001020

Cite This Page:

Helmholtz Zentrum München - German Research Center for Environmental Health. "Molecular mechanism contributing to neuronal circuit formation found." ScienceDaily. ScienceDaily, 25 April 2011. <www.sciencedaily.com/releases/2011/03/110307101303.htm>.
Helmholtz Zentrum München - German Research Center for Environmental Health. (2011, April 25). Molecular mechanism contributing to neuronal circuit formation found. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2011/03/110307101303.htm
Helmholtz Zentrum München - German Research Center for Environmental Health. "Molecular mechanism contributing to neuronal circuit formation found." ScienceDaily. www.sciencedaily.com/releases/2011/03/110307101303.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) — The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) — Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) — Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins