Featured Research

from universities, journals, and other organizations

Indications of Alzheimer's disease may be evident decades before first signs of cognitive impairment

Date:
March 28, 2011
Source:
The Mount Sinai Hospital / Mount Sinai School of Medicine
Summary:
Researchers have found that patients with Alzheimer's disease have lower glucose utilization in the brain than those with normal cognitive function, and that those decreased levels may be detectable approximately 20 years prior to the first symptoms of Alzheimer's disease. This new finding could lead to the development of novel therapies to prevent the eventual onset of Alzheimer's.

Researchers at Mount Sinai School of Medicine have found that patients with Alzheimer's disease have lower glucose utilization in the brain than those with normal cognitive function, and that those decreased levels may be detectable approximately 20 years prior to the first symptoms of Alzheimer's disease. This new finding could lead to the development of novel therapies to prevent the eventual onset of Alzheimer's.

Related Articles


The study is published online in the journal Translational Neuroscience.

Using mice modified to develop Alzheimer's disease, the research team found that when β-amyloid, an abnormal protein linked to Alzheimer's disease, starts to become detectable in the brain in its soluble toxic form, the mitochondria, or "power plants" of the cell where glucose is converted into energy, became impaired. Within the equivalent of about 20 human years, mice with decreased energy metabolism developed signs of Alzheimer's disease such as cognitive defects and impairment of the synaptic terminal, the area of brain cells important in memory formation.

"This evidence in mice validates that the diagnosis of probable Alzheimer's disease may be the end result of impairment in brain cell energy production," said the study's lead author, Giulio M. Pasinetti, MD, PhD, The Saunder Family Professor in Neurology, and Professor of Psychiatry, Geriatrics, and Adult Development at Mount Sinai School of Medicine. "Identifying that mitochondrial impairment is evident years earlier than cognitive defects is a major breakthrough."

"This new evidence could revolutionize the way we design interventions," said Merina T. Varghese, MD, co-author of the study and Postdoctoral Fellow in Neurology at Mount Sinai School of Medicine. "This study sets the stage for the development of potential novel preventions or therapies to apply in humans, even when they have normal cognitive function, to prevent the eventual onset of Alzheimer's disease."


Story Source:

The above story is based on materials provided by The Mount Sinai Hospital / Mount Sinai School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Merina Varghese, Wei Zhao, Jun Wang, Alice Cheng, Xianjuan Qian, Amna Chaudhry, Lap Ho, Giulio Maria Pasinetti. Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD Mice. Translational Neuroscience, 2011; 2 (1): 1 DOI: 10.2478/s13380-011-0011-8

Cite This Page:

The Mount Sinai Hospital / Mount Sinai School of Medicine. "Indications of Alzheimer's disease may be evident decades before first signs of cognitive impairment." ScienceDaily. ScienceDaily, 28 March 2011. <www.sciencedaily.com/releases/2011/03/110328161854.htm>.
The Mount Sinai Hospital / Mount Sinai School of Medicine. (2011, March 28). Indications of Alzheimer's disease may be evident decades before first signs of cognitive impairment. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2011/03/110328161854.htm
The Mount Sinai Hospital / Mount Sinai School of Medicine. "Indications of Alzheimer's disease may be evident decades before first signs of cognitive impairment." ScienceDaily. www.sciencedaily.com/releases/2011/03/110328161854.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins