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Quadruple therapy shows 100 percent SVR for HCV patients previously unresponsive to treatment

Date:
April 2, 2011
Source:
European Association for the Study of the Liver
Summary:
New data show that quadruple therapy in chronic hepatitis C (HCV) patients suppressed the emergence of resistant variants and resulted in a 100 percent rate of sustained virological response -- undetectable HCV RNA -- 12 weeks after treatment.

Exciting new data presented April 2 at the International Liver CongressTM 2011 show that quadruple therapy in chronic hepatitis C (HCV) patients suppressed the emergence of resistant variants and resulted in a 100% rate of sustained virological response -- undetectable HCV RNA -- 12 weeks after treatment (SVR12).

In the quadruple therapy study, HCV patients were given four drugs in combination; pegylated Interferon-alpha (PegIFN-alpha); ribavirin (RBV); and two different direct-acting antivirals (DAAs) BMS-650032 (an HCV NS3 protease inhibitor) and BMS-790052 (an HCV NS5A replication complex inhibitor).

The current standard of care (SoC) for HCV therapy is PegIFN-alpha plus RBV -- a dual therapy. The addition of DAAs (currently in phase-III clinical trials) marks the next step in treatment evolution -- a triple therapy. However, the new data suggests that quadruple therapy could be the next generation of treatment for chronic HCV patients.

Professor Heiner Wedemeyer, EASL'S Secretary General, said: "Quadruple therapy is possibly the future of HCV treatment; this study goes a way to confirming that. While it's expected that the first DAAs and triple therapy will be approved for use later this year, quadruple therapy appears to have a more profound effect on virological response, with less of a resistance problem."

The study may also provide new hope for a growing number of HCV patients who cannot be effectively treated for chronic hepatitis with current treatments.

The Phase-IIa trial looked at a cohort of 21 HCV genotype 1 null responders (patients who have failed to respond to previous treatment), of whom 19 had an unfavourable IL28B genotype, which predisposes HCV patients to treatment failure.

Only about 30% of null responders to PegIFN-alpha/RBV treatment achieve sustained virological response (SVR) when retreated with PegIFN-alpha/RBV plus telaprevir, demonstrating a high unmet medical need.


Story Source:

The above story is based on materials provided by European Association for the Study of the Liver. Note: Materials may be edited for content and length.


Cite This Page:

European Association for the Study of the Liver. "Quadruple therapy shows 100 percent SVR for HCV patients previously unresponsive to treatment." ScienceDaily. ScienceDaily, 2 April 2011. <www.sciencedaily.com/releases/2011/04/110402163850.htm>.
European Association for the Study of the Liver. (2011, April 2). Quadruple therapy shows 100 percent SVR for HCV patients previously unresponsive to treatment. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2011/04/110402163850.htm
European Association for the Study of the Liver. "Quadruple therapy shows 100 percent SVR for HCV patients previously unresponsive to treatment." ScienceDaily. www.sciencedaily.com/releases/2011/04/110402163850.htm (accessed July 30, 2014).

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