Featured Research

from universities, journals, and other organizations

Scientists discover a way to kill off tumors in cancer treatment breakthrough

Date:
April 5, 2011
Source:
Queen's University Belfast
Summary:
Scientists have developed a new treatment for cancer which rather than attacking tumors directly, prevents the growth of new blood vessels in tumors, starving them of oxygen and nutrients, thereby preventing their growth.

Scientists from the School of Pharmacy at Queen's University Belfast and Almac Discovery Ltd have developed a new treatment for cancer which rather than attacking tumours directly, prevents the growth of new blood vessels in tumours, starving them of oxygen and nutrients, thereby preventing their growth.

Targeting tumour blood vessels is not a new concept, however, this drug attacks the blood vessels using an entirely different pathway and therefore could be useful for treating tumours which don't respond to or which are resistant to current therapies of this type.

Professor Tracy Robson and her research team at Queen's, in collaboration with researchers at Almac Discovery, developed a new drug to disrupt the tumour blood supply. They have demonstrated that this leads to highly effective inhibition of tumour growth in a number of models as reported this month in Clinical Cancer Research, a journal of the American Association for Cancer Research. Almac Discovery is developing the drug candidate and expects to start clinical trials within the next year.

Professor Tracy Robson from the School of Pharmacy at Queen's explains: "By understanding the anti-angiogenic potential of the natural protein, FKBPL, we have been able to develop small peptide-based drugs that could be delivered to prevent tumour growth by cutting off their blood supply. This is highly effective in models of prostate and breast cancer.

"However, this also has the potential for the treatment of any solid tumour and we're excited about continuing to work with Almac Discovery as this drug enters clinical trials."

Dr Stephen Barr, President and Managing Director of Almac Discovery said: "This is a first class example of a collaboration between a university and industry to produce a novel approach to cancer therapy that has a real chance of helping patients."

The Almac Discovery / Queen's University drug is currently undergoing preclinical development and may provide a first-in-class therapy for targeting tumour angiogenesis by an entirely different pathway to those agents currently approved.


Story Source:

The above story is based on materials provided by Queen's University Belfast. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Valentine, M. O'Rourke, A. Yakkundi, J. Worthington, M. Hookham, R. Bicknell, H. O. McCarthy, K. McClelland, L. McCallum, H. Dyer, H. McKeen, D. J. J. Waugh, J. Roberts, J. McGregor, G. Cotton, I. James, T. Harrison, D. G. Hirst, T. Robson. FKBPL and Peptide Derivatives: Novel Biological Agents That Inhibit Angiogenesis by a CD44-Dependent Mechanism. Clinical Cancer Research, 2011; 17 (5): 1044 DOI: 10.1158/1078-0432.CCR-10-2241

Cite This Page:

Queen's University Belfast. "Scientists discover a way to kill off tumors in cancer treatment breakthrough." ScienceDaily. ScienceDaily, 5 April 2011. <www.sciencedaily.com/releases/2011/04/110404222756.htm>.
Queen's University Belfast. (2011, April 5). Scientists discover a way to kill off tumors in cancer treatment breakthrough. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2011/04/110404222756.htm
Queen's University Belfast. "Scientists discover a way to kill off tumors in cancer treatment breakthrough." ScienceDaily. www.sciencedaily.com/releases/2011/04/110404222756.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins