Featured Research

from universities, journals, and other organizations

On-off switch for key 'factor' in heart disease and cancer discovered

Date:
April 6, 2011
Source:
University of Hull
Summary:
Scientists have identified a cellular "on-off" switch that may have implications for treating cardiovascular disease and cancer.

Scientists at the University of Hull have identified a cellular 'on-off' switch that may have implications for treating cardiovascular disease and cancer. The team has found the mechanism which controls the inclusion of a protein called tissue factor into endothelial microparticles, tiny vesicles which are released from cells in the lining of blood vessels.

Related Articles


"Although tissue factor is part of the body's natural healing process, helping create clots to stop bleeding and repair injuries, high levels circulating in the blood stream can be harmful," says lead researcher Dr Camille Ettelaie. "Excessive tissue factor is linked to cardiovascular disease, including the formation of irregular blood vessels and higher risk of thrombosis, leading to heart attack and stoke."

Dr Ettelaie and co-researcher Dr Mary Collier found that two tandem amino acids within tissue factor work like an 'on-off switch' within the cells, controlling how and when it is incorporated into the microparticles and released. When a phosphate molecule is added to the first one of these two amino acids, the process starts and when added to the other, it stops.

By blocking the addition of the phosphate molecules to the first amino acid, the researchers were able to stop the process -- opening up the possibility of controlling when and how much tissue factor is released in microparticles.

"The aim of the research was to see if there might be a way to control the output of tissue factor from endothelial cells into microparticles," says Dr Ettelaie "This project focused on the vascular system and is helpful in controlling thrombosis, but tissue factor is also released in microparticles from cancer cells and linked to cell proliferation -- so our findings could have implications for treating cancer as well.

"Tissue factor is exploited by cancer cells -- they use it to speed up their growth directly, and also increase the growth of blood capillaries which supply the tumour with nutrients -- but if levels of tissue factor are too high within a cell, then the cell will die. If we could use this switch to stop cancer cells getting rid of excess tissue factor, it might be possible to kill them without causing detrimental effect to the body's normal cells."

The findings from the research -- which was partly funded by Yorkshire Cancer Research and the Castle Hill Hospital Cancer Trust Fund -- are published in the April 8 issue of Journal of Biological Chemistry.


Story Source:

The above story is based on materials provided by University of Hull. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. E. W. Collier, C. Ettelaie. Regulation of the Incorporation of Tissue Factor into Microparticles by Serine Phosphorylation of the Cytoplasmic Domain of Tissue Factor. Journal of Biological Chemistry, 2011; 286 (14): 11977 DOI: 10.1074/jbc.M110.195214

Cite This Page:

University of Hull. "On-off switch for key 'factor' in heart disease and cancer discovered." ScienceDaily. ScienceDaily, 6 April 2011. <www.sciencedaily.com/releases/2011/04/110406102131.htm>.
University of Hull. (2011, April 6). On-off switch for key 'factor' in heart disease and cancer discovered. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2011/04/110406102131.htm
University of Hull. "On-off switch for key 'factor' in heart disease and cancer discovered." ScienceDaily. www.sciencedaily.com/releases/2011/04/110406102131.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins