Featured Research

from universities, journals, and other organizations

Epileptic seizures linked to significant risk of subsequent brain tumor

Date:
April 7, 2011
Source:
BMJ-British Medical Journal
Summary:
Epileptic seizures can precede the development of a subsequent brain tumor by many years, suggests new research.

Epileptic seizures can precede the development of a subsequent brain tumour by many years, suggests research published online in the Journal of Neurology, Neurosurgery and Psychiatry.

Related Articles


The risk seems to be greatest among those aged between 15 and 44 when first admitted to hospital for an epileptic seizure, the findings show.

The researchers base their findings on first time admissions for epilepsy from the Oxford Record Linkage Study (ORLS) for 1963 to 1998, and national Hospital Episode Statistics (HES) data for England for 1999 to 2005.

These data were then linked to subsequent diagnoses of or deaths from brain tumours.

The results showed that compared with people admitted for other common and relatively minor disorders, those admitted with an epileptic seizure for the first time were just under 20 times as likely to develop a brain tumour across both sets of admissions data.

Accounting for the fact that tumours might have been missed or not recorded in the first year after admission for epilepsy, this figure fell to between a 7.5 (HES data) and almost a 9-fold (ORLS data) greater risk.

The risk of developing a cancerous brain tumour was twice as high as it was for a non-cancerous growth.

Those with epilepsy were more than 25 times as likely to develop a cancerous brain tumour and more than 10 times as likely to develop a non-cancerous growth as those admitted for other causes.

The risk was greatest in younger people aged between 15 and 44 who were between 24 times (ORLS data) and 38 times (HES data) more likely to develop a brain tumour than people of the same age without epilepsy.

Furthermore, the risk persisted for several years after the initial admission to hospital, with a more than a six-fold greater risk up to 14 years later in the ORLS data group and a five-fold higher risk up to seven years later in the HES data group.

The authors point out that brain tumours are rare, even among those with epilepsy. The overall risk of a brain tumour in 15 to 44 year olds was about 1 to 2%.

"Our study suggests that tumour as an underlying cause for epilepsy may not become apparent for several years after onset, and indicates a need for ongoing vigilance," they write.

The seizure activity may indicate either a pre-clinical phase of tumour development or could be caused directly by a tumour which doesn't show up on MRI scans, they say.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. T. Khan, W. Akhtar, C. J. Wotton, Y. Hart, M. R. Turner, M. J. Goldacre. Epilepsy and the subsequent risk of cerebral tumour: record linkage retrospective cohort study. Journal of Neurology, Neurosurgery & Psychiatry, 2011; DOI: 10.1136/jnnp.2010.228130

Cite This Page:

BMJ-British Medical Journal. "Epileptic seizures linked to significant risk of subsequent brain tumor." ScienceDaily. ScienceDaily, 7 April 2011. <www.sciencedaily.com/releases/2011/04/110406192439.htm>.
BMJ-British Medical Journal. (2011, April 7). Epileptic seizures linked to significant risk of subsequent brain tumor. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2011/04/110406192439.htm
BMJ-British Medical Journal. "Epileptic seizures linked to significant risk of subsequent brain tumor." ScienceDaily. www.sciencedaily.com/releases/2011/04/110406192439.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins