Featured Research

from universities, journals, and other organizations

Epileptic seizures linked to significant risk of subsequent brain tumor

Date:
April 7, 2011
Source:
BMJ-British Medical Journal
Summary:
Epileptic seizures can precede the development of a subsequent brain tumor by many years, suggests new research.

Epileptic seizures can precede the development of a subsequent brain tumour by many years, suggests research published online in the Journal of Neurology, Neurosurgery and Psychiatry.

The risk seems to be greatest among those aged between 15 and 44 when first admitted to hospital for an epileptic seizure, the findings show.

The researchers base their findings on first time admissions for epilepsy from the Oxford Record Linkage Study (ORLS) for 1963 to 1998, and national Hospital Episode Statistics (HES) data for England for 1999 to 2005.

These data were then linked to subsequent diagnoses of or deaths from brain tumours.

The results showed that compared with people admitted for other common and relatively minor disorders, those admitted with an epileptic seizure for the first time were just under 20 times as likely to develop a brain tumour across both sets of admissions data.

Accounting for the fact that tumours might have been missed or not recorded in the first year after admission for epilepsy, this figure fell to between a 7.5 (HES data) and almost a 9-fold (ORLS data) greater risk.

The risk of developing a cancerous brain tumour was twice as high as it was for a non-cancerous growth.

Those with epilepsy were more than 25 times as likely to develop a cancerous brain tumour and more than 10 times as likely to develop a non-cancerous growth as those admitted for other causes.

The risk was greatest in younger people aged between 15 and 44 who were between 24 times (ORLS data) and 38 times (HES data) more likely to develop a brain tumour than people of the same age without epilepsy.

Furthermore, the risk persisted for several years after the initial admission to hospital, with a more than a six-fold greater risk up to 14 years later in the ORLS data group and a five-fold higher risk up to seven years later in the HES data group.

The authors point out that brain tumours are rare, even among those with epilepsy. The overall risk of a brain tumour in 15 to 44 year olds was about 1 to 2%.

"Our study suggests that tumour as an underlying cause for epilepsy may not become apparent for several years after onset, and indicates a need for ongoing vigilance," they write.

The seizure activity may indicate either a pre-clinical phase of tumour development or could be caused directly by a tumour which doesn't show up on MRI scans, they say.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. T. Khan, W. Akhtar, C. J. Wotton, Y. Hart, M. R. Turner, M. J. Goldacre. Epilepsy and the subsequent risk of cerebral tumour: record linkage retrospective cohort study. Journal of Neurology, Neurosurgery & Psychiatry, 2011; DOI: 10.1136/jnnp.2010.228130

Cite This Page:

BMJ-British Medical Journal. "Epileptic seizures linked to significant risk of subsequent brain tumor." ScienceDaily. ScienceDaily, 7 April 2011. <www.sciencedaily.com/releases/2011/04/110406192439.htm>.
BMJ-British Medical Journal. (2011, April 7). Epileptic seizures linked to significant risk of subsequent brain tumor. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2011/04/110406192439.htm
BMJ-British Medical Journal. "Epileptic seizures linked to significant risk of subsequent brain tumor." ScienceDaily. www.sciencedaily.com/releases/2011/04/110406192439.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins