Featured Research

from universities, journals, and other organizations

Body mass index in adolescence associated with early occurrence of diabetes and heart disease

Date:
April 7, 2011
Source:
Brigham and Women's Hospital
Summary:
A study of 37,000 teenagers found that diabetes risk is mainly associated with increased body mass index close to the time of diagnosis at early adulthood, while coronary heart disease risk is associated with elevated BMI both at adolescence and adulthood.

A new 17 year follow-up study of 37,000 Israeli teenagers found that diabetes risk is mainly associated with increased body mass index (BMI) close to the time of diagnosis at early adulthood, while coronary heart disease risk is associated with elevated BMI both at adolescence and adulthood.

Related Articles


The findings are published in the April 7 issue of the New England Journal of Medicine.

Lead study author, Amir Tirosh, MD PhD, of the Endocrine Division at Brigham and Women's Hospital said, "The study suggests that the obesity problem in children and teens is likely just the tip of an iceberg for increased risk for type 2 diabetes and heart disease in adulthood."

The research team, also including Ben-Gurion Univeristy's Profesors Iris Shai and Assaf Rudich, in Beer-Sheva, Israel, along with researchers from the Israeli Defense Force (IDF) Medical Corps and Tel Hashomer, has followed 37,000 Israeli army career personnel, starting at age 17 years.

Their BMI was recorded at baseline and again every several years. During a mean follow-up period of 17 years, the average BMI of the participants rose at a rate of 0.2-0.3 units per year, mounting to an average weight gain of approximately 30 lbs between ages 17 and 30. During the study period, 1,173 new cases of diabetes and 327 new cases of heart disease were diagnosed.

When controlling for multiple risk factors for both diseases, including age, fasting blood sugar, blood lipids, blood pressure, smoking and family history, the researchers found that at age 17, BMI, even in the currently considered normal range, could predict the occurrence of both diseases. Every rise in 1 unit of BMI was associated with an approximately 10 percent increased risk for type 2 diabetes in early adulthood, and 12 percent increase in the risk for heart disease.

"Previous studies did not unequivocally confirm the association between pre-adulthood BMI and diseases in early adulthood. This study is significant because it demonstrates that the association exists within the currently-considered normal values for BMI, having distinct effect on two diseases occurring in early adulthood and in an age group that is frequently neglected," said Professor Assaf Rudich.

Remarkably, elevated risk at age 17 was significant at a BMI of 23.4 Kg/m2 or higher for diabetes and 20.9 Kg/m2 or higher for heart disease (These values correspond to a weight of 163 lbs or 146 lbs in a 5'10" male teenager, respectively). For diabetes, BMI at age 17 predicted the risk mainly since it is associated with BMI later in life. However, for heart disease, both BMI at adolescence as well as BMI at adulthood independently predicted the risk of the disease.

"It would seem that heart disease has a longer "memory" for BMI than diabetes, and history of a person's BMI should be part of risk assessment," said Profesor Iris Shai. "We do have options, not necessarily pharmacological, to offer patients to decrease their risk for heart disease. Recent intervention trials showed that nutritional habits modification can not only halt the progression of atheorsclerosis, the underlying process of heart disease, but could also reverse it."

Dr. Amir Tirosh adds, "For prevention of early occurrence of heart disease in adulthood it would seem that very early intervention to promote healthy life-style habits is warranted, even during childhood."


Story Source:

The above story is based on materials provided by Brigham and Women's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Amir Tirosh et al. Adolescent BMI Trajectory and Risk of Diabetes versus Coronary Disease. New England Journal of Medicine, 2011; 364:1315-1325; April 7, 2011 DOI: 10.1056/NEJMoa1006992

Cite This Page:

Brigham and Women's Hospital. "Body mass index in adolescence associated with early occurrence of diabetes and heart disease." ScienceDaily. ScienceDaily, 7 April 2011. <www.sciencedaily.com/releases/2011/04/110406192441.htm>.
Brigham and Women's Hospital. (2011, April 7). Body mass index in adolescence associated with early occurrence of diabetes and heart disease. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2011/04/110406192441.htm
Brigham and Women's Hospital. "Body mass index in adolescence associated with early occurrence of diabetes and heart disease." ScienceDaily. www.sciencedaily.com/releases/2011/04/110406192441.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins