Featured Research

from universities, journals, and other organizations

Frailty not a factor in adverse drug reactions among seniors, study finds

Date:
April 8, 2011
Source:
University of California - San Francisco
Summary:
Contrary to popular belief among physicians, frailty in elderly patients is not associated with an increased risk of adverse reactions to medications, according to a new study.

Contrary to popular belief among physicians, frailty in elderly patients is not associated with an increased risk of adverse reactions to medications, according to a study led by Michael Steinman, MD, a geriatrician at the San Francisco VA Medical Center.

The study of 377 patients age 65 or older appears in the online Early View section of the Journal of the American Geriatrics Society.

"There is a common, and reasonable, perception among clinicians that older people who are unable to carry out activities of daily living such as bathing, dressing, and walking without assistance are more vulnerable to adverse reactions from new medications," said Steinman, who is also an assistant professor of medicine at the University of California, San Francisco. "However, we found no association between degree of frailty and a patient's risk of adverse drug reactions."

Instead, Steinman and his fellow researchers found evidence to suggest that the greatest risk factor for an adverse drug reaction was the number of new medications that had been added recently to a patient's medication regimen.

This makes sense, observed Steinman. "If you've been on a drug for a while, the chance of your suddenly developing an adverse reaction to it is relatively low," he said, "whereas when you start a new drug, that's the time when most adverse reactions will occur."

Steinman cautioned that the study is not definitive. "Nonetheless," he said, "this indicates to physicians that they should not necessarily let their concerns about adverse reactions overrule other considerations" when deciding whether to prescribe a potentially beneficial drug to a frail elderly patient. "We want to exercise due caution," he noted, "but we don't need to be as fearful as we think we do when prescribing for our older patients."

Co-authors of the study are Brian C. Lund, PharmD, of Iowa City VA Medical Center and the University of Iowa; Yinghui Miao, MPH, of SFVAMC; W. John Boscardin, PhD, of SFVAMC and UCSF; and Peter J. Kaboli, MD, of ICVAMC and UI.

The study was supported by funds from the National Institute on Aging, the American Federation for Aging Research, the Department of Veterans Affairs, and the Center for Research in the Implementation of Innovative Strategies in Practice at ICVAMC. Some of the funds were administered by the Northern California Institute for Research and Education.

NCIRE -- The Veterans Health Research Institute -- is the largest research institute associated with a VA medical center. Its mission is to improve the health and well-being of veterans and the general public by supporting a world-class biomedical research program conducted by the UCSF faculty at SFVAMC.

SFVAMC has the largest medical research program in the national VA system, with more than 200 research scientists, all of whom are faculty members at UCSF.


Story Source:

The above story is based on materials provided by University of California - San Francisco. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michael A. Steinman, Brian C. Lund, Yinghui Miao, W. John Boscardin, Peter J. Kaboli. Geriatric Conditions, Medication Use, and Risk of Adverse Drug Events in a Predominantly Male, Older Veteran Population. Journal of the American Geriatrics Society, 2011; DOI: 10.1111/j.1532-5415.2011.03331.x

Cite This Page:

University of California - San Francisco. "Frailty not a factor in adverse drug reactions among seniors, study finds." ScienceDaily. ScienceDaily, 8 April 2011. <www.sciencedaily.com/releases/2011/04/110407092042.htm>.
University of California - San Francisco. (2011, April 8). Frailty not a factor in adverse drug reactions among seniors, study finds. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2011/04/110407092042.htm
University of California - San Francisco. "Frailty not a factor in adverse drug reactions among seniors, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/04/110407092042.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins