Featured Research

from universities, journals, and other organizations

Light, chemistry, action: New technique to target skin cancers?

Date:
April 11, 2011
Source:
University of Hull
Summary:
Targeted photodynamic therapy can completely eradicate some models of cancer, according to the new research.

Targeted photodynamic therapy can completely eradicate some models of cancer, according to the latest research by UK and Swiss scientists, published in the current issue of the British Journal of Cancer.

Related Articles


The team -- including researchers from the University of Hull and ETH Zurich -- linked light-sensitive molecules with antibodies that target tumour blood vessels. When irradiated with light, the molecules create particles known as reactive oxygen species, which in high numbers cause irreparable damage to cells.

By ensuring the light-sensitive molecules were targeted at the tumour blood vessels, the researchers could starve the tumour of oxygen and nutrients and cause it to disappear completely, with no re-growth during the following 100 days.

"There are already drugs in clinical use which target tumour blood vessels, but these only inhibit growth rather than completely kill the tumour," explains Dr Ross Boyle, from Hull's Department of Chemistry, who designs and creates the light-sensitive molecules used in the research.

"By using this form of targeted photodynamic therapy, we were able to completely kill the tumour in our models. Though this is still a long way from being used on patients, it does hold exciting potential for the treatments of some of the most common skin cancers."

However, the tumour was only completely eradicated when 'natural killer cells' -- a key part of the immune system -- were present. When the production of these was blocked, the tumour reduced in size, but did not disappear. The team believe further research is needed to determine the exact role of the immune system in the process.

Targeting light-sensitive molecules to a tumour site ensures that the treatment should be more effective even at smaller doses, improving outcomes and reducing potential side effects to patients. The technique could potentially replace more invasive forms of treatment such as surgery and radiotherapy.

Dr Boyle and his colleagues are now applying for further funding to move the research closer to clinical trials.


Story Source:

The above story is based on materials provided by University of Hull. Note: Materials may be edited for content and length.


Journal Reference:

  1. A Palumbo, F Hauler, P Dziunycz, K Schwager, A Soltermann, F Pretto, C Alonso, G F Hofbauer, R W Boyle, D Neri. A chemically modified antibody mediates complete eradication of tumours by selective disruption of tumour blood vessels. British Journal of Cancer, 2011; 104 (7): 1106 DOI: 10.1038/bjc.2011.78

Cite This Page:

University of Hull. "Light, chemistry, action: New technique to target skin cancers?." ScienceDaily. ScienceDaily, 11 April 2011. <www.sciencedaily.com/releases/2011/04/110411103713.htm>.
University of Hull. (2011, April 11). Light, chemistry, action: New technique to target skin cancers?. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2011/04/110411103713.htm
University of Hull. "Light, chemistry, action: New technique to target skin cancers?." ScienceDaily. www.sciencedaily.com/releases/2011/04/110411103713.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins