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Oral drug for multiple sclerosis significantly reduces disease activity and slows disability, study suggests

Date:
April 12, 2011
Source:
American Academy of Neurology
Summary:
The drug laquinimod reduced the number of relapses for people with multiple sclerosis (MS), in a large, long-term Phase III clinical study.

The drug laquinimod reduced the number of relapses for people with multiple sclerosis (MS), in a large, long-term Phase III clinical study that will be presented as late-breaking research at the 63rd Annual Meeting of the American Academy of Neurology, April 9-16, 2011, in Honolulu.

The study involved 1,106 people with relapsing-remitting MS in 24 countries. The participants received either a once-daily oral dose of 0.6 milligrams of laquinimod or a matching placebo for two years. Eighty percent of those taking laquinimod and 77 percent of those taking the placebo finished the two-year study.

Patients treated with laquinimod experienced a statistically significant reduction of 23 percent in annual relapse rate, compared to patients treated with a placebo. Additionally, there was a reduction of 36 percent in disability progression, as well as a 33 percent reduction in brain atrophy for those people treated with laquinimod.

"These exciting results confirm that laquinimod has a significant impact on progression of disability and disease activity, while maintaining a high safety profile," said lead author Giancarlo Comi, MD, director of the Department of Neurology and Institute of Experimental Neurology at the Scientific Institute and University Vita-Salute San Raffaele in Milan, Italy. "This may be attributed to the novel mechanism of action of laquinimod, which effectively and safely addressed both the acute inflammatory activity and the accumulation of irreversible tissue damage. This suggests a substantial future role for laquinimod in the treatment of MS."

Laquinimod was safe and well tolerated. Overall frequencies of adverse events were low and comparable to those observed in the placebo group. "The incidence of liver enzyme elevation was higher in laquinimod treated patients," said Comi. "However, these elevations were temporary, reversible and did not lead to any signs of liver problems."

The study was supported by Teva Pharmaceuticals.


Story Source:

The above story is based on materials provided by American Academy of Neurology. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Neurology. "Oral drug for multiple sclerosis significantly reduces disease activity and slows disability, study suggests." ScienceDaily. ScienceDaily, 12 April 2011. <www.sciencedaily.com/releases/2011/04/110411163801.htm>.
American Academy of Neurology. (2011, April 12). Oral drug for multiple sclerosis significantly reduces disease activity and slows disability, study suggests. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2011/04/110411163801.htm
American Academy of Neurology. "Oral drug for multiple sclerosis significantly reduces disease activity and slows disability, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/04/110411163801.htm (accessed April 20, 2014).

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