Featured Research

from universities, journals, and other organizations

Artificial pancreas may improve overnight control of diabetes in adults

Date:
April 18, 2011
Source:
BMJ-British Medical Journal
Summary:
Two small randomized trials suggest that closed loop insulin delivery (also known as an artificial pancreas) may improve overnight blood glucose control and reduce the risk of nocturnal hypoglycemia (a sudden drop in blood glucose levels during the night) in adults with type 1 diabetes.

Two small randomised trials published online in the British Medical Journal suggest that closed loop insulin delivery (also known as an artificial pancreas) may improve overnight blood glucose control and reduce the risk of nocturnal hypoglycaemia (a sudden drop in blood glucose levels during the night) in adults with type 1 diabetes.

Related Articles


The number of people with type 1 diabetes is increasing at a rate of 3% per year, particularly in white northern European populations. Lifelong insulin therapy is needed to control blood glucose levels, but the risk of hypoglycaemia remains a major challenge, especially during the night.

Recent advances have led to the development of a closed loop insulin delivery system that automatically computes insulin dose according to glucose levels detected by a sensor. Previous studies have shown that this system is effective in children and adolescents, but its effectiveness in adults is unknown.

So a team of researchers, led by Roman Hovorka from the University of Cambridge, carried out two studies to compare the safety and efficacy of overnight closed loop insulin delivery with conventional insulin pump therapy in adults with type 1 diabetes.

The group consisted of 24 adults (10 men and 14 women) aged 18-65, who had used insulin pump therapy for at least three months.

In the first study, 12 participants were twice monitored overnight after consuming a medium sized meal (60 g carbohydrate) at 7pm: they were randomly assigned to use either closed loop delivery of insulin or conventional insulin pump therapy and then, on a night one to three weeks later, they used the other delivery method. In the second study, the other 12 participants were twice monitored overnight (using one or other of the two insulin delivery methods) after consuming a larger meal (100 g carbohydrate) at 8.30pm, accompanied by alcohol.

The time spent with blood glucose levels in the target range increased by up to 28% during overnight closed loop insulin delivery. Closed loop delivery also lowered glucose variability overnight and significantly reduced the time spent hyperglycaemic.

These findings provide further evidence that overnight closed loop delivery can operate safely, effectively, and consistently across different age groups, insulin sensitivities, and lifestyle conditions, conclude the authors.

They add that the closed loop system "may in future allow more flexible lifestyles in conjunction with improved glycaemic control for people with type 1 diabetes."

In an accompanying editorial, Professor Boris Kovatchev from the University of Virginia says that, while closed loop control shows promise in a research setting, further development and system miniaturisation is needed in practice to greatly improve the health and lives of people with type 1 diabetes.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Journal References:

  1. R. Hovorka, K. Kumareswaran, J. Harris, J. M. Allen, D. Elleri, D. Xing, C. Kollman, M. Nodale, H. R. Murphy, D. B. Dunger, S. A. Amiel, S. R. Heller, M. E. Wilinska, M. L. Evans. Overnight closed loop insulin delivery (artificial pancreas) in adults with type 1 diabetes: crossover randomised controlled studies. BMJ, 2011; 342 (apr13 5): d1855 DOI: 10.1136/bmj.d1855
  2. B. Kovatchev. Closed loop control for type 1 diabetes. BMJ, 2011; 342 (apr13 5): d1911 DOI: 10.1136/bmj.d1911

Cite This Page:

BMJ-British Medical Journal. "Artificial pancreas may improve overnight control of diabetes in adults." ScienceDaily. ScienceDaily, 18 April 2011. <www.sciencedaily.com/releases/2011/04/110415083200.htm>.
BMJ-British Medical Journal. (2011, April 18). Artificial pancreas may improve overnight control of diabetes in adults. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2011/04/110415083200.htm
BMJ-British Medical Journal. "Artificial pancreas may improve overnight control of diabetes in adults." ScienceDaily. www.sciencedaily.com/releases/2011/04/110415083200.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins