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Routine rotavirus vaccination in Brazil has reduced diarrhea deaths in children

Date:
April 21, 2011
Source:
Public Library of Science
Summary:
Rotavirus vaccination in all areas of Brazil is associated with reduced diarrhea-related deaths and hospital admissions in children aged under five years, a new study reports.

Rotavirus vaccination in all areas of Brazil is associated with reduced diarrhea-related deaths and hospital admissions in children aged under five years, reports a study in PLoS Medicine.

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Manish Patel from the Centers for Disease Control and Prevention in Atlanta, Georgia, USA, and colleagues show that these real-world impact data -- what actually happens in reality rather than in strictly controlled clinical trial settings -- are consistent with the clinical trials and conclude that their study strengthens the evidence base for use of rotavirus vaccination as an effective measure for controlling severe and fatal childhood diarrhea.

Brazil has a high incidence of diarrhea-related deaths and hospital admissions in young children and, in July 2006, the Brazilian Ministry of Health introduced rotavirus vaccination simultaneously in all 27 states, allowing the authors to conduct a ''before'' and ''after'' intervention analysis.

Using routinely collected national data, the authors found that in 2007 an estimated 80% of infants received two doses of rotavirus vaccine, and by 2009 that this proportion rose to 84% of children younger than one year of age. In the three years following the introduction of rotavirus vaccination, diarrhea-related mortality rates and admissions among children aged under five years were, respectively, 22% and 17% lower than expected, with a cumulative total of 1,500 fewer diarrhea deaths and 130,000 fewer hospital admissions.

Furthermore, the largest reductions in deaths and admissions were among children who had the highest rates of vaccination (less than two years of age), and the lowest reductions were among children who were not age-eligible for vaccination during the study period (aged 2-4 years).

The authors say: "This time-series analysis provides evidence of substantial reductions following the introduction of rotavirus vaccination of both diarrhea-related deaths and diarrhea-related hospital admissions from a large middle-income country in the Americas with both developing and developed regions."

They continue: "In middle-income countries that are not eligible for financial support from donors, the potential reductions in diarrhea-related hospital admissions and other health-care costs will be important for cost-effectiveness considerations to justify the purchase of these relatively expensive vaccines."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Greice Madeleine Ikeda do Carmo, Catherine Yen, Jennifer Cortes, Alessandra Araújo Siqueira, Wanderson Kleber de Oliveira, Juan José Cortez-Escalante, Ben Lopman, Brendan Flannery, Lucia Helena de Oliveira, Eduardo Hage Carmo, Manish Patel. Decline in Diarrhea Mortality and Admissions after Routine Childhood Rotavirus Immunization in Brazil: A Time-Series Analysis. PLoS Medicine, 2011; 8 (4): e1001024 DOI: 10.1371/journal.pmed.1001024

Cite This Page:

Public Library of Science. "Routine rotavirus vaccination in Brazil has reduced diarrhea deaths in children." ScienceDaily. ScienceDaily, 21 April 2011. <www.sciencedaily.com/releases/2011/04/110419205519.htm>.
Public Library of Science. (2011, April 21). Routine rotavirus vaccination in Brazil has reduced diarrhea deaths in children. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2011/04/110419205519.htm
Public Library of Science. "Routine rotavirus vaccination in Brazil has reduced diarrhea deaths in children." ScienceDaily. www.sciencedaily.com/releases/2011/04/110419205519.htm (accessed November 23, 2014).

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