Featured Research

from universities, journals, and other organizations

Air pollution exposure affects chances of developing premenopausal breast cancer, study finds

Date:
April 20, 2011
Source:
University at Buffalo
Summary:
Exposure to air pollution early in life and when a woman gives birth to her first child may alter her DNA and may be associated with pre-menopausal breast cancer later in life, researchers have shown.

Exposure to air pollution early in life and when a woman gives birth to her first child may alter her DNA and may be associated with premenopausal breast cancer later in life, researchers at the University at Buffalo have shown.

Related Articles


The findings indicated that higher air pollution exposure at birth may alter DNA methylation, which may increase levels of E-cadherin, a protein important to the adhesion of cells, a function that plays an essential role in maintaining a stable cellular environment and assuring healthy tissues.

Methylation is a chemical process that has been implicated in determining which genes in a cell are active, a process essential to normal cellular function.

Women with breast cancer who lived in a region with more air pollution were more likely to have the alteration in the DNA in their tumor than those who lived in a less-polluted region, results showed.

Higher air pollution concentration at the time of first child birth also was associated with changes in p16, a gene involved in tumor suppression, according to findings.

Results of the research were presented April 6 at the 2011 American Association for Cancer Research meeting in Orlando, Fla.

Lead investigator Katharine Dobson, MPH, an epidemiology doctoral student and research assistant in UB's Department of Social and Preventive Medicine, says of the findings: "To our knowledge, this is the first study to examine exposure to ambient air pollution at key points in a woman's lifetime.

"The investigation looked for an association between exposure to pollution and alterations to DNA that influence the presence or absence of key proteins. Such genetic changes are thought to be major contributors to cancer development and progression, including at very early stages," Dobson says.

The study is based on data from the Western New York Exposures and Breast Cancer (WEB) study, which collected information from 1,170 women with recently diagnosed breast cancer and 2,116 healthy women who lived in New York's Erie and Niagara counties between 1996 and 2001. This research involved only cancer cases.

Participants provided information on where they were born, where they lived at the time of their first menstrual period, and, if they had children, where they lived when they bore their first child. Data from air monitors operating in the relevant time periods was used to determine the amount of particulate matter at each participant's residence at those time periods. Air pollution data from 87 sites in Western New York was matched with residence location at year of birth, year of menarche and year of first child birth.

"We found that decreased E-cadherin promoter methylation was associated with higher exposure at birth, and increased p16 methylation with higher exposure at the time of a first child birth," says Dobson.

"For breast cancer cases, menopausal status appeared to modify the association between air pollution exposure and E-cadherin promoter methylation, with premenopausal women more susceptible to these early exposures than postmenopausal women."

More research is needed to determine the role of air pollution in DNA methylation in breast cancer development and progression, and to address changing air pollution contents and levels over time, Dobson notes

Jo L. Freudenheim, PhD; Menghua Tao, MD, PhD; Jing Nie, PhD; and Matthew Bonner, PhD, all from UB, contributed to the study, as well as researchers from Lombardi Comprehensive Cancer Center, Georgetown University, Washington D.C.; Roswell Park Cancer Institute, Buffalo, N.Y.; Potomac Hospital, Woodbridge, Va.; and University of Nevada Health Sciences System, Las Vegas, Nev.

The study was funded by the National Cancer Institute.


Story Source:

The above story is based on materials provided by University at Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University at Buffalo. "Air pollution exposure affects chances of developing premenopausal breast cancer, study finds." ScienceDaily. ScienceDaily, 20 April 2011. <www.sciencedaily.com/releases/2011/04/110420125508.htm>.
University at Buffalo. (2011, April 20). Air pollution exposure affects chances of developing premenopausal breast cancer, study finds. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2011/04/110420125508.htm
University at Buffalo. "Air pollution exposure affects chances of developing premenopausal breast cancer, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/04/110420125508.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins