Featured Research

from universities, journals, and other organizations

Screening very preterm infants for autism at 18 months often inaccurate

Date:
May 1, 2011
Source:
American Academy of Pediatrics
Summary:
Extremely premature infants who screen positive for autism spectrum disorder at 18 months of age may not actually have autism. Rather, they may fail screening tests due to an unrelated cognitive or language delay.

Extremely premature infants who screen positive for autism spectrum disorder (ASD) at 18 months of age may not actually have autism. Rather, they may fail screening tests due to an unrelated cognitive or language delay, according to research presented on May 1, at the Pediatric Academic Societies (PAS) annual meeting in Denver.

An estimated one in 110 U.S. children has ASD, a group of complex developmental brain disorders that affect behavior, social skills and communication. The American Academy of Pediatrics (AAP) recommends that pediatricians screen all children for ASD at 18-24 months of age, and those who fail the screening test should be referred for a formal assessment.

Based on the AAP guidelines, many neonatal intensive care unit follow-up clinics that monitor former extremely preterm infants have instituted this screening protocol. However, it is not known how accurate early screening is in identifying ASD in this high-risk population.

Researchers, led by Bonnie E. Stephens, MD, FAAP, assistant professor of pediatrics at Brown University's Alpert School of Medicine and neonatologist/developmental and behavioral pediatrician at Women & Infants Hospital of Rhode Island, suspected that many preterm infants who screen positive for ASD at 18 months do not have ASD but are failing these screens due to a cognitive or language delay, both of which are common in extremely preterm infants at 18 months.

To test their hypothesis, the investigators screened infants born at their hospital before 28 weeks' gestation with three measures, one of which was designed specifically for use in high-risk populations such as preterm infants. They sought to determine the rate of false-positive screens for ASD at 18 and 30 months of age and to explore the relationship between a positive screen and cognitive and language delay.

A total of 152 infants were screened for ASD at 18 months (age corrected for prematurity), and 116 infants were screened at 30 months corrected age.

Results showed that 18 percent screened positive for ASD at 18 months, while 10 percent screened positive at 30 months. Only 3 percent of infants had positive results on all three screens at either point in time, and all of the infants who screened positive for ASD on all three screening tests at 30 months were later diagnosed with ASD.

In addition, a positive screen at 18 or 30 months was associated with cognitive and language delay.

"While these findings have important implications, further work is needed," Dr. Stephens said. "To determine which of these infants actually have ASD, a study that includes a formal diagnostic assessment on all children with a failed screen is needed."

Dr. Stephens and her colleagues are seeking funding to support a multicenter study of more than 500 preterm children. "This will allow us to determine the true rate of ASD in this population, the rate of false-positive screens at 18 and 30 months, the optimal time to screen, and the optimal ASD screening tool for the extremely preterm population."


Story Source:

The above story is based on materials provided by American Academy of Pediatrics. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Pediatrics. "Screening very preterm infants for autism at 18 months often inaccurate." ScienceDaily. ScienceDaily, 1 May 2011. <www.sciencedaily.com/releases/2011/05/110501183811.htm>.
American Academy of Pediatrics. (2011, May 1). Screening very preterm infants for autism at 18 months often inaccurate. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2011/05/110501183811.htm
American Academy of Pediatrics. "Screening very preterm infants for autism at 18 months often inaccurate." ScienceDaily. www.sciencedaily.com/releases/2011/05/110501183811.htm (accessed October 1, 2014).

Share This



More Mind & Brain News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Stopping School Violence

Stopping School Violence

Ivanhoe (Oct. 1, 2014) A trauma doctor steps out of the hospital and into the classroom to teach kids how to calmly solve conflicts, avoiding a trip to the ER. Video provided by Ivanhoe
Powered by NewsLook.com
Pineal Cysts: Debilitating Pain

Pineal Cysts: Debilitating Pain

Ivanhoe (Oct. 1, 2014) A tiny cyst in the brain that can cause debilitating symptoms like chronic headaches and insomnia, and the doctor who performs the delicate surgery to remove them. Video provided by Ivanhoe
Powered by NewsLook.com
Burning Away Brain Tumors

Burning Away Brain Tumors

Ivanhoe (Oct. 1, 2014) Doctors are 'cooking' brain tumors. Hear how this new laser-heat procedure cuts down on recovery time. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins