Featured Research

from universities, journals, and other organizations

Protein discovered that could help prevent the spread of cancer

Date:
May 5, 2011
Source:
Queen's University
Summary:
A protein capable of halting the spread of breast cancer cells could lead to a therapy for preventing or limiting the spread of the disease.

Dr. Andrew Craig with an image that shows the "invadopodia" of a breast cancer cell protruding into surrounding tissue and degrading the tissue barriers. It is this process of metastasis or cancer spread that Dr. Craig's team hope to be able to lessen or prevent with future therapies
Credit: Queen's University

A protein capable of halting the spread of breast cancer cells could lead to a therapy for preventing or limiting the spread of the disease.

"Cancer researchers want to design new therapeutic strategies in which the metastasis or spreading stage of cancer can be blocked," explains Andrew Craig, lead researcher and a professor in Queen's Department of Biochemistry and Cancer Research Institute. "Patients stand a much better chance of survival if the primary tumor is the only tumor that needs to be treated."

The regulatory protein identified by Dr Craig's team inhibits the spread of cancer cells by removing and breaking down an invasive enzyme on the surface of cancer cells. If it remains unchecked, this enzyme degrades and modifies surrounding tissues, facilitating the spread of cancer through the body.

Dr. Craig hopes that his team's findings may help develop more targeted therapies that have a specific inhibitory function on this enzyme that is implicated in certain metastatic cancers.

Traditional therapies that have been used to counteract the invasive nature of this particular enzyme also destroy other enzymes that are important for the body's normal physiological function.

The researchers examined a network of proteins that are responsible for controlling the shape of cancer cells. They focused specifically on parts of the cell that protrude into surrounding body tissues, allowing the cancer cell to degrade surrounding tissue barriers.

Normal cells also produce similar protrusions as part of a healthy physiological process that allows cells to move through body tissues during an immune response.

During the spread of cancer these normally healthy mechanisms are coopted by cancer cells, allowing the cancer to break through tissue boundaries and colonize distant tissues. This process of cancer spread is known as metastasis and is frequently the cause of cancer-related deaths.

This research, which was funded by the Canadian Breast Cancer Foundation, will be featured on the cover of the May issue of the Journal of Cell Science.


Story Source:

The above story is based on materials provided by Queen's University. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Hu, A. Mukhopadhyay, P. Truesdell, H. Chander, U. K. Mukhopadhyay, A. S. Mak, A. W. B. Craig. Cdc42-interacting protein 4 is a Src substrate that regulates invadopodia and invasiveness of breast tumors by promoting MT1-MMP endocytosis. Journal of Cell Science, 2011; 124 (10): 1739 DOI: 10.1242/jcs.078014

Cite This Page:

Queen's University. "Protein discovered that could help prevent the spread of cancer." ScienceDaily. ScienceDaily, 5 May 2011. <www.sciencedaily.com/releases/2011/05/110504155115.htm>.
Queen's University. (2011, May 5). Protein discovered that could help prevent the spread of cancer. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2011/05/110504155115.htm
Queen's University. "Protein discovered that could help prevent the spread of cancer." ScienceDaily. www.sciencedaily.com/releases/2011/05/110504155115.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins