Featured Research

from universities, journals, and other organizations

New marker offers hope for more reliable detection of prostate cancer

Date:
May 11, 2011
Source:
Uppsala University
Summary:
A new, promising marker for diagnosing prostate cancer has been discovered by researchers in Sweden with the aid of a unique method. The study may lead to more reliable diagnoses and fewer unnecessary operations.

A new, promising marker for diagnosing prostate cancer has been discovered by Uppsala researchers with the aid of a unique method developed at the Department of Immunology, Genetics and Pathology. The study, being published this week in the journal Proceedings of the National Academy of Sciences, may lead to more reliable diagnoses and fewer unnecessary operations.

Related Articles


The PSA marker used for diagnosing prostate cancer today has been criticized for false positive responses, leading to unnecessary operations. There is therefore great interest in finding new and better biomarkers.

- In the limited patient material examined in our study, blood levels of so-called prostasomes seem to correlate more closely with the severity of the disease than do PSA levels, says Masood Kamali-Moghaddam, a scientist in Professor Ulf Landegren's research team at the Department of Immunology, Genetics, and Pathology.

The team has previously developed a uniquely specific and sensitive method, called proximity ligation, for effective determination of proteins, and the method has now been adapted for detecting prostasomes.

One of the co-authors of the present study, Professor Gunnar Ronquist, showed 30 years ago that prostate cells pump out large quantities of a tiny membrane-coated particle in semen, which he named prostasomes. The hypothesis is that, in cancer, rather than winding up in semen, prostasomes are pumped out into the surrounding cancer tissue in invasive cancer. Therefore, prostasomes could be expected to occur at elevated levels in blood in cases of prostate cancer.

It has not been possible earlier to detect prostasomes in blood, but the researchers devised a unique test that requires several different antibodies to simultaneously recognize proteins on the surface of the prostasomes, and this allowed them to detect elevated levels of prostasomes in the blood of patients with prostate cancer.

"We are hopeful that this type of marker will prove valuable not only for prostate cancer but also in several other common tumor types," says Masood Kamali- Moghaddam.


Story Source:

The above story is based on materials provided by Uppsala University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gholamreza Tavoosidana, Gunnar Ronquist, Spyros Darmanis, Junhong Yan, Lena Carlsson, Di Wu, Tim Conze, Pia Ek, Axel Semjonow, Elke Eltze, Anders Larsson, Ulf D. Landegren, and Masood Kamali-Moghaddam. Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer. Proceedings of the National Academy of Sciences, 2011; DOI: 10.1073/pnas.1019330108

Cite This Page:

Uppsala University. "New marker offers hope for more reliable detection of prostate cancer." ScienceDaily. ScienceDaily, 11 May 2011. <www.sciencedaily.com/releases/2011/05/110509151240.htm>.
Uppsala University. (2011, May 11). New marker offers hope for more reliable detection of prostate cancer. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2011/05/110509151240.htm
Uppsala University. "New marker offers hope for more reliable detection of prostate cancer." ScienceDaily. www.sciencedaily.com/releases/2011/05/110509151240.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins