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Most common form of inherited intellectual disability may be treatable, review suggests

Date:
May 18, 2011
Source:
American Chemical Society
Summary:
Advancements over the last 10 years in understanding intellectual disability have led to the once-unimaginable possibility that the condition may be treatable, a review of more than 100 studies on the topic has concluded.

Advancements over the last 10 years in understanding intellectual disability (ID) have led to the once-unimaginable possibility that ID may be treatable, a review of more than 100 studies on the topic has concluded.

It appears in ACS Chemical Neuroscience.

Aileen Healy and colleagues explain that people long have viewed intellectual disability as permanent and untreatable, with medical care focusing on relieving some of the symptoms rather than correcting the underlying causes. That includes Fragile X syndrome (FXS), the most common inherited form of intellectual disability. FXS occurs in an array of forms, ranging from mild learning disabilities to more severe intellectual and developmental disabilities. It is the most common known cause of autism or autistic-like behaviors.

Scientists are now beginning to get a handle on the changes that happen to cells and molecules in the body because of a mutation in the Fragile X Mental Retardation 1 gene. That gene contains instructions for making a key protein vital for nerve function in the brain, and does not work properly in FXS. With a better understanding of the biological effects of the mutation, the scientists say that treatments for FXS and similar disorders now seem possible. In addition, several drugs tested in humans seem promising.

"In conclusion, the recent clinical introduction of multiple compounds representing a variety of mechanistic approaches to the disorder represents an exciting opportunity to realize the mission of implementing effective treatments of ID," say the researchers.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Aileen Healy, Roger Rush, Timothy Ocain. Fragile X Syndrome: An Update on Developing Treatment Modalities. ACS Chemical Neuroscience, 2011; 110401091440015 DOI: 10.1021/cn200019z

Cite This Page:

American Chemical Society. "Most common form of inherited intellectual disability may be treatable, review suggests." ScienceDaily. ScienceDaily, 18 May 2011. <www.sciencedaily.com/releases/2011/05/110517132634.htm>.
American Chemical Society. (2011, May 18). Most common form of inherited intellectual disability may be treatable, review suggests. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2011/05/110517132634.htm
American Chemical Society. "Most common form of inherited intellectual disability may be treatable, review suggests." ScienceDaily. www.sciencedaily.com/releases/2011/05/110517132634.htm (accessed September 18, 2014).

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