Featured Research

from universities, journals, and other organizations

Antibody production gets confused during long-term spaceflight

Date:
May 19, 2011
Source:
Federation of American Societies for Experimental Biology
Summary:
The trip to Mars just got more difficult since researchers discovered that antibodies that fight off disease might become compromised during long-term space flights. A new report shows that antibodies produced in space are less effective than those produced on Earth. This reduced effectiveness of antibodies makes astronauts more susceptible to illness, increasing the danger posed by bacteria and viruses likely to coexist with wayfaring astronauts.

The trip to Mars just got a little more difficult now that French researchers have discovered that antibodies used to fight off disease might become seriously compromised during long-term space flight. In a new report published online in the FASEB Journal, the scientists show that antibodies produced in space are less effective than those produced on terra firma. The reduced effectiveness of antibodies makes astronauts more susceptible to illness, while increasing the danger posed by bacteria and viruses likely to coexist with wayfaring astronauts.

"We hope to find efficient pharmacological and/or nutritional countermeasures to alterations of the immune system that could be useful to astronauts and to people who have weak immune systems on Earth because of infections, aging, or chronic stress exposure," said Jean-Pol Frippiat, a researcher involved in the work from the Faculty of Medicine, Development and Immunogenetics at the Universit้ Henri Poincar้-Nancy, Vandœuvre-l่s-Nancy, France.

To make their discovery, Frippiat and colleagues conducted studies using three groups of amphibians. Amphibians were chosen for the work because they use the same cellular mechanisms to produce antibodies as humans do. The first group of amphibians was immunized in space, the second was immunized on Earth, and the third was not immunized at all. Comparison of the antibodies produced revealed that the quality of the antibodies generated by the group immunized in space was decreased. This suggests that spaceflight conditions alter the immune system and affect its ability to protect against infections and tumors, posing a serious risk for astronauts.

"This paper shows that somatic hypermutation occurs at a lower frequency in spaceflight and brings together yet more evidence that the immune system is dependent on gravity," said Millie Hughes-Fulford, Ph.D., NASA Science Astronaut; Professor, Department of Biochemistry and Biophysics, UCSF; Director, Laboratory of Cell Growth, VAMC/UCSF; and editorial board member of the FASEB Journal. "Dependence on gravity should be no surprise since all of earth's jawed vertebrates developed in earth's gravity, and it would be logical to expect that some systems would require gravity for normal function."

"Outer space may be the final frontier, but this research shows that our inner space could pose the greatest threat to the success of a mission," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "These explorers will have to be prepared not only for the challenges of extremely hostile environments, but also those posed by microbial stowaways, even those with which we peacefully co-exist on Earth."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Bascove, N. Gueguinou, B. Schaerlinger, G. Gauquelin-Koch, J.-P. Frippiat. Decrease in antibody somatic hypermutation frequency under extreme, extended spaceflight conditions. The FASEB Journal, 2011; DOI: 10.1096/fj.11-185215

Cite This Page:

Federation of American Societies for Experimental Biology. "Antibody production gets confused during long-term spaceflight." ScienceDaily. ScienceDaily, 19 May 2011. <www.sciencedaily.com/releases/2011/05/110519113014.htm>.
Federation of American Societies for Experimental Biology. (2011, May 19). Antibody production gets confused during long-term spaceflight. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2011/05/110519113014.htm
Federation of American Societies for Experimental Biology. "Antibody production gets confused during long-term spaceflight." ScienceDaily. www.sciencedaily.com/releases/2011/05/110519113014.htm (accessed April 18, 2014).

Share This



More Space & Time News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Earth's Near-Twin Found Orbiting Red Dwarf

Earth's Near-Twin Found Orbiting Red Dwarf

Newsy (Apr. 17, 2014) — The newly-discovered planet is roughly the size of Earth and could have liquid water on its surface. Video provided by Newsy
Powered by NewsLook.com
New Baby Moon 'Peggy' Spotted In Saturn's Rings

New Baby Moon 'Peggy' Spotted In Saturn's Rings

Newsy (Apr. 15, 2014) — A bump in the rings could be a half-mile-wide miniature moon. It was found by accident in Cassini probe images. Video provided by Newsy
Powered by NewsLook.com
Americas Glimpse Total Lunar Eclipse

Americas Glimpse Total Lunar Eclipse

AFP (Apr. 15, 2014) — A total lunar eclipse, the first since December 2011, took place early Tuesday morning with the Americas getting the best glimpse. Duration: 1:19 Video provided by AFP
Powered by NewsLook.com
NASA Showcases Lunar Eclipse

NASA Showcases Lunar Eclipse

AP (Apr. 15, 2014) — Star gazers in parts of North and South America got a rare treat early Tuesday morning - a total eclipse of the moon. (April 15) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins