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Threshold hemoglobin and mortality in people with stable coronary disease

Date:
May 31, 2011
Source:
Public Library of Science
Summary:
In a new study, researchers report that, in people with stable coronary disease, there were threshold haemoglobin values below which mortality increased in a graded, continuous fashion.
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In a new article in PLoS Medicine, Anoop Shah of University College London and colleagues report that, in people with stable coronary disease, there were threshold haemoglobin values below which mortality increased in a graded, continuous fashion. As well as a systematic review and statistical analysis of previous studies, the researchers conducted a retrospective analysis of patients from a prospective observational cohort.

Their findings suggest that there are thresholds of haemoglobin that are associated with increased risk of mortality in patients with angina or myocardial infarction, and, though limited by the observational nature of its results, the study supports the rationale for conducting future randomised controlled trials to assess whether haemoglobin levels are causal and whether clinicians should intervene to increase haemoglobin levels, for example by oral iron supplementation.

The authors say that "Irrespective of a possible causal, reversible relationship between

haemoglobin concentration and mortality, further research is warranted to assess what incremental prognostic value haemoglobin might offer in risk stratifying patients with stable coronary disease."


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The above post is reprinted from materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Anoop D. Shah, Owen Nicholas, Adam D. Timmis, Gene Feder, Keith R. Abrams, Ruoling Chen, Aroon D. Hingorani, Harry Hemingway. Threshold Haemoglobin Levels and the Prognosis of Stable Coronary Disease: Two New Cohorts and a Systematic Review and Meta-Analysis. PLoS Medicine, 2011; 8 (5): e1000439 DOI: 10.1371/journal.pmed.1000439

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Public Library of Science. "Threshold hemoglobin and mortality in people with stable coronary disease." ScienceDaily. ScienceDaily, 31 May 2011. <www.sciencedaily.com/releases/2011/05/110531180932.htm>.
Public Library of Science. (2011, May 31). Threshold hemoglobin and mortality in people with stable coronary disease. ScienceDaily. Retrieved July 28, 2015 from www.sciencedaily.com/releases/2011/05/110531180932.htm
Public Library of Science. "Threshold hemoglobin and mortality in people with stable coronary disease." ScienceDaily. www.sciencedaily.com/releases/2011/05/110531180932.htm (accessed July 28, 2015).

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