Featured Research

from universities, journals, and other organizations

Mechanism in saliva production discovered

Date:
June 3, 2011
Source:
University of Louisville
Summary:
Researchers are one step closer to helping millions of people whose salivary glands no longer work because of disease or damage from treatment of diseases.

University of Louisville researchers are one step closer to helping millions of people whose salivary glands no longer work because of disease or damage from treatment of diseases.

Related Articles


The scientific finding of Douglas Darling, PhD, professor, Department of Oral Health and Rehabilitation, UofL School of Dentistry, and his team identified a protein sorting mechanism used by the salivary gland. The National Institutes of Health supported study published online first this week in the Journal of Dental Research.

The scientific discovery could form the basis for advanced therapies for patients whose salivary glands are damaged or no longer function due to radiation therapy, prescription drugs or Sjogren's Syndrome -- an immune system disorder often defined by its two most common symptoms -- dry eyes and a dry mouth.

The salivary glands are essential for lubrication, defense and beginning digestion in the mouth. The largest of the salivary glands -- the parotid -- secretes important proteins into the saliva. As with all salivary glands, it has multiple secretion pathways, therefore it must sort proteins destined for saliva into the correct pathway for secretion. This can be tricky as there are seven possible pathways. One pathway takes proteins to the salivary duct, other pathways carry different proteins to the 'back' side of the cell to be secreted into the blood or to form a supportive matrix for the cells. Transport along these pathways occurs by sorting the proteins into vesicles (hollow membrane sacs) that carry their "cargo" to the correct destination.

Conventional thought was that cargo proteins are moved into the forming vesicles by attaching to sorting receptor proteins. Darling and his team have discovered a completely new approach, suggesting the reason no salivary sorting receptor protein has been found is that it may not exist.

In Darling's new model, the salivary cargo protein, Parotid Secretory Protein (PSP), selectively and directly binds to a rare lipid, a type of fat molecule called PtdIns(3,4)P2, present only in certain cell membranes -- and only present on one side of the membrane. Darling also found PtdIns(3,4)P2 can flip to the inner part of the vesicle membrane -giving PSP the opportunity to bind it.

"These data imply that phosphatidylinositol-phosphate lipids like PtdIns(3,4)P2 may have multiple functions on the inner surface of organelles," Darling said. "This is contrary to the current belief that their functions are always limited to one surface of the cell membrane."

The next step is for Darling and his team to identify the molecular components used for flipping PtdIns(3,4)P2, and develop approaches to test ways to manipulate this potential protein sorting mechanism.

The study, Parotid Secretory Protein Binds Phosphatidylinositol (3,4) Bisphosphate can be found on the Journal of Dental Research website.


Story Source:

The above story is based on materials provided by University of Louisville. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. G. Venkatesh, D. Goyal, A. L. Carenbauer, D. S. Darling. Parotid Secretory Protein Binds Phosphatidylinositol (3,4) Bisphosphate. Journal of Dental Research, 2011; DOI: 10.1177/0022034511410699

Cite This Page:

University of Louisville. "Mechanism in saliva production discovered." ScienceDaily. ScienceDaily, 3 June 2011. <www.sciencedaily.com/releases/2011/06/110602143208.htm>.
University of Louisville. (2011, June 3). Mechanism in saliva production discovered. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/2011/06/110602143208.htm
University of Louisville. "Mechanism in saliva production discovered." ScienceDaily. www.sciencedaily.com/releases/2011/06/110602143208.htm (accessed November 1, 2014).

Share This



More Health & Medicine News

Saturday, November 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins