Featured Research

from universities, journals, and other organizations

Near infrared fluorescence lights up hidden blood clots

Date:
June 8, 2011
Source:
Society of Nuclear Medicine
Summary:
New research may mark the expansion of a novel imaging agent for an optical technique called near-infrared fluorescence, which uses light energy to glean information about cells and tissues. NIRF combined with the newly synthesized agent can image dangerous blood clots hiding inside elusive veins, most commonly within the deep tissues of the thighs and pelvis, but potentially also in the coronary arteries. The agent uses a biomarker that seeks out a peptide (the building blocks of proteins) called fibrin that is actively involved in the formation of blood clots.

Research presented at SNM's 58th Annual Meeting may mark the expansion of a novel imaging agent for an optical technique called near-infrared fluorescence (NIRF), which uses light energy to glean information about cells and tissues. NIRF combined with the newly synthesized agent can image dangerous blood clots hiding inside elusive veins, most commonly within the deep tissues of the thighs and pelvis, but potentially also in the coronary arteries. The agent uses a biomarker that seeks out a peptide (the building blocks of proteins) called fibrin that is actively involved in the formation of blood clots.

Related Articles


"This new near-infrared fluorescence agent is important in the field of molecular imaging because it offers very high-resolution imaging capabilities and has high translational potential," says Tetsuya Hara, MD, PhD, Massachusetts General Hospital, Boston, Mass. "Specifically, the agent's fibrin peptide has already been tested in phase II clinical trials. The availability of a high-resolution fibrin sensor is important for two reasons: intravascular NIRF imaging of coronary-sized arteries is now possible, and coupling the fibrin peptide with this technique may allow researchers to study coronary artery plaques and stents, which could potentially help us identify patients at increased risk of heart attack."

Near-infrared fluorescence targets tissues by hitting them with near-infrared light energy that is absorbed by fluorophores -- components of a molecule that make it fluorescent -- and then emitted at a longer wavelength (fluorescence). Researchers can detect fluorescence signals by studying the wavelengths of light energy that is released from the tissues. This method can be used to evaluate patients for a range of diseases such as cancer and Alzheimer's disease, as well as cardiovascular disease like deep vein thrombosis.

In conjunction with the new near-infrared fluorescence fibrin-targeted peptide, investigators were able to successfully detect fibrin-rich deep vein thrombosis with both intravital fluorescence microscopy and noninvasive fluorescence molecular tomography, which allows researchers to acquire information about tissues by analyzing how light is absorbed by and scattered from tissues. By coupling the fibrin peptide agent (EP-2104R) with rapidly emerging intravascular NIRF imaging, researchers now have the opportunity to study micro-thrombi on coronary artery plaques and coronary stents that are at especially high risk for thrombosis and vessel occlusion, the main cause of heart attacks. This could help clinicians predict potential heart attacks and other major cardiovascular events before it is too late, thus potentially saving the lives of patients.


Story Source:

The above story is based on materials provided by Society of Nuclear Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Society of Nuclear Medicine. "Near infrared fluorescence lights up hidden blood clots." ScienceDaily. ScienceDaily, 8 June 2011. <www.sciencedaily.com/releases/2011/06/110606131603.htm>.
Society of Nuclear Medicine. (2011, June 8). Near infrared fluorescence lights up hidden blood clots. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2011/06/110606131603.htm
Society of Nuclear Medicine. "Near infrared fluorescence lights up hidden blood clots." ScienceDaily. www.sciencedaily.com/releases/2011/06/110606131603.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

AFP (Jan. 29, 2015) Oxfam International has called for a multi-million dollar post-Ebola "Marshall Plan", with financial support given by wealthy countries, to help Guinea, Sierra Leone and Liberia to recover. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Are We Winning The Fight Against Ebola?

Are We Winning The Fight Against Ebola?

Newsy (Jan. 29, 2015) The World Health Organization announced the fight against Ebola has entered its second phase as the number of cases per week has steadily dropped. Video provided by Newsy
Powered by NewsLook.com
Calif. Health Officials Campaign Against E-Cigarettes

Calif. Health Officials Campaign Against E-Cigarettes

Newsy (Jan. 29, 2015) The California Health Department says e-cigarettes are a public health risk for both smokers and those who inhale e-cig smoke secondhand. Video provided by Newsy
Powered by NewsLook.com
Measles Scare Sends 66 Calif. Students Home

Measles Scare Sends 66 Calif. Students Home

AP (Jan. 29, 2015) Officials say 66 students at a Southern California high school have been told to stay home through the end of next week because they may have been exposed to measles and are not vaccinated. (Jan. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins