Featured Research

from universities, journals, and other organizations

Yo-yo dieting vs. obesity? Dieters may be healthier, live longer, mouse study suggests

Date:
June 7, 2011
Source:
Ohio University
Summary:
Yo-yo dieters may be healthier and live longer than those who stay obese, a new study suggests. Mice that switched between a high-fat and low-fat diet every four weeks during their approximate two-year lifespan lived about 25 percent longer and had better blood glucose levels than obese animals that ate a high-fat diet. The yo-yo dieters also lived about as long as a control group of mice steadily fed a low-fat diet.

A new study suggests that yo-yo dieters may be healthier and live longer than those who stay obese.
Credit: © Karen Roach / Fotolia

Yo-yo dieters may be healthier and live longer than those who stay obese, a new Ohio University study in mice suggests.

Related Articles


Mice that switched between a high-fat and low-fat diet every four weeks during their approximate two-year lifespan lived about 25 percent longer and had better blood glucose levels than obese animals that ate a high-fat diet. The yo-yo dieters also lived about as long as a control group of mice steadily fed a low-fat diet.

Some experts argue that constantly shedding and regaining pounds can be harmful to health. The new research, presented at the annual meeting of the Endocrine Society in Boston, suggests, however, that yo-yo dieting is preferable to remaining obese and not dieting at all.

"If the conventional wisdom is true, it would discourage a lot of overweight people from losing weight," said study lead author Edward List, a scientist at Ohio University's Edison Biotechnology Institute. "The new research shows that the simple act of gaining and losing weight does not seem detrimental to lifespan."

About 34 percent of American adults are considered to be obese; an additional 34 percent are classified as overweight, according to the Centers for Disease Control and Prevention. Although millions of Americans diet each year, research has shown that few people maintain long-term weight loss.

In the first study on yo-yo dieting of its kind, List and colleagues followed 30 mice on one of three dietary regimens over the course of a little over two years, the typical lifespan of this particular strain of laboratory mouse. The animals on the high-fat diet ate more, weighed more and had higher levels of body fat and fasting blood glucose. They also become glucose intolerant, or pre-diabetic, said List, whose research is supported by the National Institutes of Health, AMVETS and Ohio University.

The health profile of the mice on the yo-yo diet declined during their high-fat food phases, but their weight and blood glucose levels returned to normal levels during their low-fat diet stages. Lifespan -- the "gold standard" for lifelong health status -- was 2.04 years for the yo-yo dieting mice, compared to 1.5 years for the obese mice. The control group lived, on average, for 2.09 years.

Although replicating the research in humans is ideal, List said, it would be challenging to pursue a long-term controlled diet study. Various factors, including illness, can impact weight cycling. Mice can serve as a good model for obesity research, he noted, as they allow researchers to follow the effects of diet choices on lifespan over a relatively short time period.

"The study adds to our understanding of the benefit of losing weight," he said. "I would hope that this encourages people to not give up."

List plans to expand the study to a larger population of mice. He'll also further examine preliminary findings that suggest that the yo-yo dieting animals experienced a reduction in cytokine levels. High levels of cytokine are linked to increased inflammation, which is associated with diseases such as diabetes, heart disease and cancer.

Co-authors of the study are former Ohio University student Jacob Wright-Piekarski, now a medical student with St. Louis University, and Edison Biotechnology Institute scientists Darlene Berryman, an associate professor in the College of Health Sciences and Professions, and John Kopchick, Goll-Ohio Eminent Scholar of molecular biology in the College of Osteopathic Medicine.


Story Source:

The above story is based on materials provided by Ohio University. Note: Materials may be edited for content and length.


Cite This Page:

Ohio University. "Yo-yo dieting vs. obesity? Dieters may be healthier, live longer, mouse study suggests." ScienceDaily. ScienceDaily, 7 June 2011. <www.sciencedaily.com/releases/2011/06/110606142342.htm>.
Ohio University. (2011, June 7). Yo-yo dieting vs. obesity? Dieters may be healthier, live longer, mouse study suggests. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2011/06/110606142342.htm
Ohio University. "Yo-yo dieting vs. obesity? Dieters may be healthier, live longer, mouse study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/06/110606142342.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins