Featured Research

from universities, journals, and other organizations

Dietary changes appear to affect levels of biomarkers associated with Alzheimer's disease

Date:
June 14, 2011
Source:
JAMA and Archives Journals
Summary:
Following a low-saturated fat and low-glycemic index diet appears to modulate the risk of developing dementia that proceeds to Alzheimer's disease (AD), although making a switch to this dietary pattern may not protect those already experiencing cognitive difficulty, according to a new study.

Following a low-saturated fat and low-glycemic index diet appears to modulate the risk of developing dementia that proceeds to Alzheimer's disease (AD), and making a switch to this dietary pattern may provide some benefit to those who are experiencing cognitive difficulty, according to a report in the June issue of Archives of Neurology, one of the JAMA/Archives journals.

Related Articles


Previous research has suggested multiple links between diet and cognitive ability, the authors note as background information. Health conditions in which insulin resistance (the body's inability to use insulin effectively) is a factor -- obesity, type 2 diabetes, cardiovascular disease and high cholesterol levels -- have also been associated with "pathological brain aging." However, studies of specific foods have not found conclusive evidence of an influence on Alzheimer's risk. "Thus," the authors write, "a more promising approach to the study of dietary factors in AD might entail the use of whole-diet interventions, which have greater ecologic validity and preserve the nutritional milieu in which fat and carbohydrate consumption occurs."

Jennifer L. Bayer-Carter, M.S., from Veterans Affairs Puget Sound Health Care System, Seattle, and colleagues sought to compare a high-saturated fat/high-simple carbohydrate diet (a macronutrient pattern associated with type 2 diabetes and insulin resistance) with a low-saturated fat/low-simple carbohydrate diet; the interventions were named HIGH and LOW, respectively. The authors evaluated the effects of these diets in 20 older adults who were healthy and 29 older adults who had amnestic mild cognitive impairment (aMCI), meaning they experienced some memory problems; the latter condition is often considered a precursor to AD. In a four-week randomized, controlled trial, 24 participants followed the HIGH diet and 25 followed the LOW diet. The researchers studied participants' performance on memory tests as well as their levels of biomarkers (biological substances indicative of AD), such as insulin, cholesterol, blood glucose levels, blood lipid levels and components of cerebrospinal fluid (CSF).

Results of the study were different for the group that had aMCI and the group of healthy participants. In the latter group, the LOW diet decreased some CSF biomarkers of AD as well as total cholesterol levels. However, among individuals with aMCI, the LOW diet increased levels of these biomarkers. Some changes to biomarkers, such as CSF insulin levels, were observed in both groups. Additionally, the LOW diet improved performance on delayed visual recall tests for both healthy and memory-impaired participants, but did not affect scores on other cognitive measures.

The findings indicate that "for healthy adults, the HIGH diet moved CSF biomarkers in a direction that may characterize a presymptomatic stage of AD," explain the authors. They believe that the different results of the unhealthy diet in participants with aMCI may be due to the diet's short duration. "The therapeutic effects of longer-term dietary intervention may be a promising avenue of exploration," the authors conclude. "In addition, identification of the pathophysiologic changes underlying dietary effects may reveal important therapeutic targets that can be modulated through targeted dietary or pharmacologic intervention."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jennifer L. Bayer-Carter; Pattie S. Green; Thomas J. Montine; Brian VanFossen; Laura D. Baker; G. Stennis Watson; Laura M. Bonner; Maureen Callaghan; James B. Leverenz; Brooke K. Walter; Elaine Tsai; Stephen R. Plymate; Nadia Postupna; Charles W. Wilkinson; Jing Zhang; Johanna Lampe; Steven E. Kahn; Suzanne Craft. Diet Intervention and Cerebrospinal Fluid Biomarkers in Amnestic Mild Cognitive Impairment. Archives of Neurology, 2011; 68 (6): 743-752 DOI: 10.1001/archneurol.2011.125

Cite This Page:

JAMA and Archives Journals. "Dietary changes appear to affect levels of biomarkers associated with Alzheimer's disease." ScienceDaily. ScienceDaily, 14 June 2011. <www.sciencedaily.com/releases/2011/06/110613162057.htm>.
JAMA and Archives Journals. (2011, June 14). Dietary changes appear to affect levels of biomarkers associated with Alzheimer's disease. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2011/06/110613162057.htm
JAMA and Archives Journals. "Dietary changes appear to affect levels of biomarkers associated with Alzheimer's disease." ScienceDaily. www.sciencedaily.com/releases/2011/06/110613162057.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins