Featured Research

from universities, journals, and other organizations

Immune response to tumour cells could aid cancer battle

Date:
June 15, 2011
Source:
University of Leicester
Summary:
New research in the UK has yielded a novel immunotherapeutic approach with potential for cancer treatment.

New research at the University of Leicester has yielded a novel immunotherapeutic approach with potential for cancer treatment.

Malignant tumours are the second main cause of death worldwide, with haematological malignancies representing 10%. Current treatment strategies, such as chemotherapy, radiotherapy, stem cell transplantation, or a combination of them, are mostly effective but may induce serious side effects to normal tissues. In addition, tumours are developing resistance against most of these conventional therapies.

A PhD student with the Department of Infection, Immunity and Inflammation, Yehia Mohamed, has shown that tumour "hybrid" cell lines can induce immune responses against tumour cells in the lab, as opposed to directly attacking them. As a result, the patients' tumour cells, as well as related cell lines, were killed, his findings reveal.

With tumour cells evolving mechanisms for evading the immune responses and making the development of strategies for inducing strong anti-tumour immunity difficult, Mohamed's research comes at a right time by providing a new solution for this issue.

Mohamed explained: "The tumour-specific cellular vaccines were created by fusing blood related tumour cells with the immunostimulatory cell line HMy2. These fusion cells showed enhanced ability to stimulate immune responses in blood cells from both tumour patients and normal individuals. His results suggest that hybrid cell lines could be used as immunotherapeutic agents for treatment of several types of haematological and non-haematological tumours.

"These data provide promising hope for developing more effective, safe, and long-lasting therapies of different types of tumours."

Dr Michael Browning, of the Department of Infection, Immunity and Inflammation, added: "There is growing evidence that the immune system plays a role in preventing cancer development, and that activating immune effectors in the right way may offer novel forms of cancer treatment.

"If developed further, the methods used in Mohamed's PhD project could offer a new way of treating certain cancer patients, by inducing tumour-killing cells from their blood in the lab, and then giving them back to the patient to seek out and kill any remaining tumour cells."


Story Source:

The above story is based on materials provided by University of Leicester. Note: Materials may be edited for content and length.


Cite This Page:

University of Leicester. "Immune response to tumour cells could aid cancer battle." ScienceDaily. ScienceDaily, 15 June 2011. <www.sciencedaily.com/releases/2011/06/110615062304.htm>.
University of Leicester. (2011, June 15). Immune response to tumour cells could aid cancer battle. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2011/06/110615062304.htm
University of Leicester. "Immune response to tumour cells could aid cancer battle." ScienceDaily. www.sciencedaily.com/releases/2011/06/110615062304.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins