Featured Research

from universities, journals, and other organizations

Exercise associated with longer survival after brain cancer diagnosis

Date:
June 21, 2011
Source:
Duke University Medical Center
Summary:
Brain cancer patients who are able to exercise live significantly longer than sedentary patients, scientists report.

Brain cancer patients who are able to exercise live significantly longer than sedentary patients, scientists at the Duke Cancer Institute report.

The finding, published online June 20 in the Journal of Clinical Oncology, adds to recent research that exercise improves how cancer patients feel during and after treatments, and may also extend their lives.

"This provides some initial evidence that we need to look at the effects of exercise interventions, not only to ease symptoms but also to impact progression and survival," said Lee W. Jones, PhD, associate professor in the Duke Cancer Institute and senior author of the study.

Although the study was not designed to test whether regular exercise actually causes longer survival among brain cancer patients, it established a strong correlation that could give doctors and patients a more accurate prognosis of long-term survival.

The study enrolled 243 patients at the Preston Robert Tisch Brain Tumor Center at Duke with advanced recurrent gliomas, lethal brain malignancies that typically result in a median life expectancy of less than six months.

The patients who reported participating in regular, brisk exercise - the equivalent of an energetic walk five days a week for 30 minutes -- had significantly prolonged survival, living a median 21.84 months vs. 13.03 months for the most sedentary patients.

The self-reported exercise behavior offered an important additional means of predicting survival among the glioma patients beyond other measures traditionally used for prognosis, including a six-minute walk test.

Jones said the walk test is a good way to gauge the functional capacity of people with heart failure or other cardiac or pulmonary disorders, but it may not be informative for brain cancer patients who frequently suffer dizzy spells and other neurological problems that hamper walking.

Jose Cortes, a Duke patient who has battled inoperable anaplastic astrocytoma since 2009, has been an avid proponent of the power of exercise during his treatment.

"I exercised regularly prior to my illness and I wanted to stay as active as possible," Cortes said. "But it was impossible for me to do things that I could do easily before. My first goals in physical therapy were to put on my shoes without tipping over and keep my equilibrium while walking and talking or walking and turning my head."

As he met and surpassed his early goals, he began walking for 30 minutes a day and last year joined a Zumba fitness-dance class at his local YMCA.

"I wanted to be able to exercise because it makes me feel alive again," Cortes said. He cautioned that exercise is no cure -- his cancer has responded well to chemotherapy -- but he said being active helps both physically and mentally.

"Exercise is a very good way to overcome the side effects of your disease," he said. "You can feel more positive about your life even if you are in a terminal state. The most important thing is to just do it at your own pace and do your best."

The Duke study demonstrates that if doctors know about their patients' exercise regimens, they will have a better way to assess long-term outcomes. Jones said an accurate prognosis is important to determine the overall health of patients, potential tolerance for certain types of treatment, and eligibility for clinical trials.

Jones said a major goal of his research is to discover why exercise may lead to improvements in survival following a cancer diagnosis.

"Discovering these mechanisms could provide new insights into cancer progression," Lee said. "It could also lead to novel studies where exercise is combined with certain cancer therapies to see if both interventions together are more effective at inhibiting cancer recurrence or progression, not just minimizing the adverse side effects of the cancer therapies."

Jones conducted the study with colleagues in the Preston Robert Tisch Brain Tumor Center at Duke. Authors include Emily Ruden; David A. Reardon, M.D.; April D. Coan; James E. Herndon II, PhD; Whitney E. Hornsby; Miranda West; Diane R. Fels, PhD; Annick Desjardins, M.D.; James J. Vredenburgh, M.D.; Emily Waner; Allan H. Friedman, M.D.; Henry S. Friedman, M.D.; and Katherine B. Peters, M.D., PhD.

The study was supported with funds from George and Susan Beischer.


Story Source:

The above story is based on materials provided by Duke University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. E. Ruden, D. A. Reardon, A. D. Coan, J. E. Herndon, W. E. Hornsby, M. West, D. R. Fels, A. Desjardins, J. J. Vredenburgh, E. Waner, A. H. Friedman, H. S. Friedman, K. B. Peters, L. W. Jones. Exercise Behavior, Functional Capacity, and Survival in Adults With Malignant Recurrent Glioma. Journal of Clinical Oncology, 2011; DOI: 10.1200/JCO.2011.34.9852

Cite This Page:

Duke University Medical Center. "Exercise associated with longer survival after brain cancer diagnosis." ScienceDaily. ScienceDaily, 21 June 2011. <www.sciencedaily.com/releases/2011/06/110621114153.htm>.
Duke University Medical Center. (2011, June 21). Exercise associated with longer survival after brain cancer diagnosis. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2011/06/110621114153.htm
Duke University Medical Center. "Exercise associated with longer survival after brain cancer diagnosis." ScienceDaily. www.sciencedaily.com/releases/2011/06/110621114153.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins