Featured Research

from universities, journals, and other organizations

Diabetic kidney disease more prevalent in US

Date:
June 21, 2011
Source:
JAMA and Archives Journals
Summary:
Over the past two decades the prevalence of diabetic kidney disease in the US increased in direct proportion to the prevalence of diabetes itself, according to a new study.

Over the past 2 decades the prevalence of diabetic kidney disease in the U.S. increased in direct proportion to the prevalence of diabetes itself, according to a study in the June 22/29 issue of JAMA.

Diabetic kidney disease (DKD) is a common complication of diabetes and the leading cause of chronic kidney disease in the developed world. Approximately 40 percent of persons with diabetes develop DKD, which also accounts for nearly half of all new cases of end-stage renal disease (ESRD) in the United States. "Over time, the prevalence of DKD may increase due to the expanding size of the diabetes population or decrease due to the implementation of diabetes therapies," according to background information in the article the authors write.

Ian H. de Boer, M.D., M.S., of the University of Washington, Seattle, and colleagues examined trends in the prevalence of DKD in the United States and changes in disease manifestations among persons with diabetes over the past 2 decades. The study included data from the Third National Health and Nutrition Examination Survey (NHANES III) from 1988-1994 (n = 15,073), NHANES 1999-2004 (n = 13,045), and NHANES 2005-2008 (n = 9,588). Participants with diabetes were defined by levels of hemoglobin A 1c of 6.5 percent or greater, use of glucose-lowering medications, or both (n = 1,431 in NHANES III; n = 1,443 in NHANES 1999-2004; n=1,280 in NHANES 2005-2008). Diabetic kidney disease was defined as diabetes with albuminuria (ratio of urine albumin to creatinine 30 mg/g or greater), impaired glomerular filtration rate (less than 60 mL/min/1.73 m 2 estimated using the Chronic Kidney Disease Epidemiology Collaboration formula), or both.

The researchers found that the prevalence of DKD in the U.S. population was 2.2 percent in 1988-1994, 2.8 percent in 1999-2004, and 3.3 percent in 2005-2008, with the demographically adjusted increase in DKD prevalence being 18 percent from 1988-1994 to 1999-2004 and 34 percent from 1988-1994 to 2005-2008. The estimated numbers of persons with DKD in the U.S. at any given point in time increased from 3.9 million during 1988-1994 to 5.5 million during 1999-2004 to 6.9 million during 2005-2008.

The proportion of persons with diabetes taking glucose-lowering medications increased from 56.2 percent to 74.2 percent and the use of renin-angiotensin-aldosterone system inhibitors increased from 11.2 percent to 40.6 percent. The prevalence of impaired GFR increased from 14.9 percent in 1988-1994 to 17.7 percent in 2005-2008. The prevalence of impaired albuminuria decreased from 27.3 percent to 23.7 percent during these time periods, but this was not statistically significant.

"In conclusion, DKD has become more prevalent in the U.S. population over the last 2 decades and will likely contribute increasingly to health care costs and mortality. Among persons with diabetes, clinical manifestations of DKD shifted to include more impaired GFR but the prevalence of any DKD did not change despite increased use of diabetes-related medications," the authors write.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. I. H. de Boer, T. C. Rue, Y. N. Hall, P. J. Heagerty, N. S. Weiss, J. Himmelfarb. Temporal Trends in the Prevalence of Diabetic Kidney Disease in the United States. JAMA: The Journal of the American Medical Association, 2011; 305 (24): 2532 DOI: 10.1001/jama.2011.861

Cite This Page:

JAMA and Archives Journals. "Diabetic kidney disease more prevalent in US." ScienceDaily. ScienceDaily, 21 June 2011. <www.sciencedaily.com/releases/2011/06/110621164714.htm>.
JAMA and Archives Journals. (2011, June 21). Diabetic kidney disease more prevalent in US. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2011/06/110621164714.htm
JAMA and Archives Journals. "Diabetic kidney disease more prevalent in US." ScienceDaily. www.sciencedaily.com/releases/2011/06/110621164714.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins