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Genetic finding offers hope for orphan disease

Date:
June 23, 2011
Source:
University of North Carolina School of Medicine
Summary:
New research offers hope for people with a rare disorder called Chuvash polycythemia.

New research conducted at UNC Lineberger Comprehensive Cancer Center, offers hope for people with a rare disorder called Chuvash polycythemia.

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Polycythemia is a disease characterized by excessive production of red blood cells. Symptoms include an enlarged spleen, blood clots, an increased risk of stroke, and in some cases the disease is a precursor to acute leukemia. While 95 percent of polycythemia cases are associated with a mutation in the JAK2 gene, a small number of patients have a mutation in the von Hippel-Lindau gene that produces a protein called pVHL.

"It was thought that these two types of polycythemia would need treatments targeting different biochemical pathways," says William Kim, MD, one of the study authors and a member of UNC Lineberger Comprehensive Cancer Center. Kim is an assistant professor of Medicine and Genetics at UNC-Chapel Hill.

"We found that -- despite their different origins -- both types of disease display activation of JAK2. This is exciting because there are JAK2 inhibitors in late stage clinical trials that look promising for patients with JAK2 mutant polycythemia. Our work in laboratory models shows that inhibition of JAK2 is an effective strategy for both types of the disease. Under normal circumstances, the small number of people with a Chuvash VHL mutation would make this type of polycythemia an orphan disease. There are simply not enough patients to make the development of a targeted treatment worthwhile for pharmaceutical companies," he added.

The study results were published earlier this week in the journal Nature Medicine.

Kim cautions that, while the JAK2 inhibitors look very promising in laboratory models of Chuvash polycythemia, they have not yet been tested in humans.

Other UNC Lineberger collaborators include Bing Zhou, PhD, and Samuel Heathcote, BS. Scientists from the University of Toronto, University of Pennsylvania, University of California, San Diego, Howard Hughes Medical Institute and The Hospital for Sick Children in Toronto, Ontario also participated in the research.

The research was funded by the Canadian Cancer Society, the U.S. National Institutes of Health and U.S. Department of Defense. Dr. Kim is a Damon Runyon Merck clinical investigator.


Story Source:

The above story is based on materials provided by University of North Carolina School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ryan C Russell, Roxana I Sufan, Bing Zhou, Pardeep Heir, Severa Bunda, Stephanie S Sybingco, Samantha N Greer, Olga Roche, Samuel A Heathcote, Vinca W K Chow, Lukasz M Boba, Terri D Richmond, Michele M Hickey, Dwayne L Barber, David A Cheresh, M Celeste Simon, Meredith S Irwin, William Y Kim, Michael Ohh. Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. Nature Medicine, 2011; DOI: 10.1038/nm.2370

Cite This Page:

University of North Carolina School of Medicine. "Genetic finding offers hope for orphan disease." ScienceDaily. ScienceDaily, 23 June 2011. <www.sciencedaily.com/releases/2011/06/110622115309.htm>.
University of North Carolina School of Medicine. (2011, June 23). Genetic finding offers hope for orphan disease. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2011/06/110622115309.htm
University of North Carolina School of Medicine. "Genetic finding offers hope for orphan disease." ScienceDaily. www.sciencedaily.com/releases/2011/06/110622115309.htm (accessed January 27, 2015).

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