Featured Research

from universities, journals, and other organizations

Answers for treating obesity-related diseases may reside in fat tissue, study shows

Date:
July 5, 2011
Source:
Boston University Medical Center
Summary:
Researchers have shown that the quality -- not just the quantity -- of adipose, or fat, tissue is a significant contributing factor in the development of inflammation and vascular disease in obese individuals.

Researchers at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) have shown that the quality -- not just the quantity -- of adipose, or fat, tissue is a significant contributing factor in the development of inflammation and vascular disease in obese individuals. The study, which is a special feature on the iPad version of the Journal of the American College of Cardiology, provides compelling evidence that the answer to treating cardiovascular disease and other obesity-related disorders, such as type 2 diabetes and cancer, might be found in the adipose tissue itself.

While obesity is a leading preventable cause of death in the United States, its prevalence continues to increase rapidly among individuals of all ethnicities and age groups. According to the National Institutes of Health, more than 33 percent of men and women above the age of 20 in the United States are obese and 68% are overweight.

Led by Noyan Gokce, MD, a cardiologist at BMC and an associate professor of medicine at BUSM, the researchers examined adipose tissue samples from both lean and obese individuals. The study subjects, all of whom were receiving care at BMC, included 109 obese men and women and 17 lean men and women between the ages of 21 and 55.

After obtaining the samples, the tissue was biopsied and evaluated for the amount of inflammation present in the tissue. They then performed a vascular ultrasound on the forearm artery to examine blood vessel function. After compiling the information, the researchers saw that lean individuals exhibited no adipose inflammation and normal vascular function whereas the obese individuals exhibited significant inflammation and poor vascular function.

While these study findings are consistent with other epidemiological obesity studies, this research team identified that 30 percent of the obese subjects demonstrated reduced fat inflammation, less insulin resistance, and their vascular function was similar to a lean person despite severe obesity. The study suggests that humans prone to inflammation in association with weight gain may be more susceptible to cardiovascular and metabolic disease risks.

"While it is widely believed that obesity and inflammation are linked to cardiovascular disease, this study shows not all obese individuals exhibit inflammation that can lead to cardiovascular disease, type 2 diabetes and cancer," said Gokce, the study's senior author. "Once we identify what harmful products adipose tissue is producing that is linked to causing systemic inflammation, we can explore treatments against it that could potentially combat the development of several debilitating obesity-related disorders."

This study was funded by The National Institutes of Health. Other researchers involved with the study include: Melissa G. Farb, PhD, Sherman Bigornia, MA, Melanie Mott, MS, RD, Kahraman Tanriverdi, PhD, Kristine M. Morin, MPH, Jane E. Freedman, MD, Lija Joseph, MD, Donald T. Hess, MD, Caroline M. Apovian, MD, and Joseph A. Vita, MD.


Story Source:

The above story is based on materials provided by Boston University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Melissa G. Farb, Sherman Bigornia, Melanie Mott, Kahraman Tanriverdi, Kristine M. Morin, Jane E. Freedman, Lija Joseph, Donald T. Hess, Caroline M. Apovian, Joseph A. Vita, Noyan Gokce. Reduced Adipose Tissue Inflammation Represents an Intermediate Cardiometabolic Phenotype in Obesity. Journal of the American College of Cardiology, 2011; 58: 232-237 DOI: 10.1016/j.jacc.2011.01.051

Cite This Page:

Boston University Medical Center. "Answers for treating obesity-related diseases may reside in fat tissue, study shows." ScienceDaily. ScienceDaily, 5 July 2011. <www.sciencedaily.com/releases/2011/07/110704174736.htm>.
Boston University Medical Center. (2011, July 5). Answers for treating obesity-related diseases may reside in fat tissue, study shows. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2011/07/110704174736.htm
Boston University Medical Center. "Answers for treating obesity-related diseases may reside in fat tissue, study shows." ScienceDaily. www.sciencedaily.com/releases/2011/07/110704174736.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins