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Gold nanoparticles bring scientists closer to a treatment for cancer

Date:
July 6, 2011
Source:
University of Southampton
Summary:
Scientists have developed smart nanomaterials, which can disrupt the blood supply to cancerous tumors. They have shown that a small dose of gold nanoparticles can activate or inhibit genes that are involved in angiogenesis -- a complex process responsible for the supply of oxygen and nutrients to most types of cancer.

A schematic illustration of different types of gold nanoparticles used in the experiments. NR is gold nanorods, HG is hollow gold nanoparticles, SP is spherical gold nanoparticles and CS is core-shell silica-gold nanoparticles.
Credit: Image courtesy of University of Southampton

Scientists at the University of Southampton have developed smart nanomaterials, which can disrupt the blood supply to cancerous tumours.

The team of researchers, led by Physics lecturer Dr Antonios Kanaras, showed that a small dose of gold nanoparticles can activate or inhibit genes that are involved in angiogenesis -- a complex process responsible for the supply of oxygen and nutrients to most types of cancer.

"The peptide-functionalised gold nanoparticles that we synthesised are very effective in the deliberate activation or inhibition of angiogenic genes," said Dr Kanaras.

The team went a step further to control the degree of damage to the endothelial cells using laser illumination. Endothelial cells construct the interior of blood vessels and play a pivotal role in angiogenesis.

The researchers also found that the gold particles could be used as effective tools in cellular nanosurgery.

"We have found that gold nanoparticles can have a dual role in cellular manipulation. Applying laser irradiation, we can use the nanoparticles either to destroy endothelial cells, as a measure to cut the blood supply to tumours, or to deliberately open up the cellular membrane in order to deliver a drug efficiently," said Dr Kanaras.

The researchers are almost midway through their research and have published two related papers with another one submitted for publication and four more planned throughout this year. Their major target is to develop a complete nanotechnology toolkit to manipulate angiogenesis. To make this a reality within five to ten years they continue to seek funding.


Story Source:

The above story is based on materials provided by University of Southampton. Note: Materials may be edited for content and length.


Journal References:

  1. Dorota Bartczak, Otto L. Muskens, Timothy M. Millar, Tilman Sanchez-Elsner, Antonios G. Kanaras. Laser-Induced Damage and Recovery of Plasmonically Targeted Human Endothelial Cells. Nano Letters, 2011; 11 (3): 1358 DOI: 10.1021/nl104528s
  2. Dorota Bartczak, Tilman Sanchez-Elsner, Fethi Louafi, Timothy M. Millar, Antonios G. Kanaras. Receptor-Mediated Interactions between Colloidal Gold Nanoparticles and Human Umbilical Vein Endothelial Cells. Small, 2011; 7 (3): 388 DOI: 10.1002/smll.201001816

Cite This Page:

University of Southampton. "Gold nanoparticles bring scientists closer to a treatment for cancer." ScienceDaily. ScienceDaily, 6 July 2011. <www.sciencedaily.com/releases/2011/07/110705071518.htm>.
University of Southampton. (2011, July 6). Gold nanoparticles bring scientists closer to a treatment for cancer. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2011/07/110705071518.htm
University of Southampton. "Gold nanoparticles bring scientists closer to a treatment for cancer." ScienceDaily. www.sciencedaily.com/releases/2011/07/110705071518.htm (accessed October 23, 2014).

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