Featured Research

from universities, journals, and other organizations

Gold nanoparticles bring scientists closer to a treatment for cancer

Date:
July 6, 2011
Source:
University of Southampton
Summary:
Scientists have developed smart nanomaterials, which can disrupt the blood supply to cancerous tumors. They have shown that a small dose of gold nanoparticles can activate or inhibit genes that are involved in angiogenesis -- a complex process responsible for the supply of oxygen and nutrients to most types of cancer.

A schematic illustration of different types of gold nanoparticles used in the experiments. NR is gold nanorods, HG is hollow gold nanoparticles, SP is spherical gold nanoparticles and CS is core-shell silica-gold nanoparticles.
Credit: Image courtesy of University of Southampton

Scientists at the University of Southampton have developed smart nanomaterials, which can disrupt the blood supply to cancerous tumours.

The team of researchers, led by Physics lecturer Dr Antonios Kanaras, showed that a small dose of gold nanoparticles can activate or inhibit genes that are involved in angiogenesis -- a complex process responsible for the supply of oxygen and nutrients to most types of cancer.

"The peptide-functionalised gold nanoparticles that we synthesised are very effective in the deliberate activation or inhibition of angiogenic genes," said Dr Kanaras.

The team went a step further to control the degree of damage to the endothelial cells using laser illumination. Endothelial cells construct the interior of blood vessels and play a pivotal role in angiogenesis.

The researchers also found that the gold particles could be used as effective tools in cellular nanosurgery.

"We have found that gold nanoparticles can have a dual role in cellular manipulation. Applying laser irradiation, we can use the nanoparticles either to destroy endothelial cells, as a measure to cut the blood supply to tumours, or to deliberately open up the cellular membrane in order to deliver a drug efficiently," said Dr Kanaras.

The researchers are almost midway through their research and have published two related papers with another one submitted for publication and four more planned throughout this year. Their major target is to develop a complete nanotechnology toolkit to manipulate angiogenesis. To make this a reality within five to ten years they continue to seek funding.


Story Source:

The above story is based on materials provided by University of Southampton. Note: Materials may be edited for content and length.


Journal References:

  1. Dorota Bartczak, Otto L. Muskens, Timothy M. Millar, Tilman Sanchez-Elsner, Antonios G. Kanaras. Laser-Induced Damage and Recovery of Plasmonically Targeted Human Endothelial Cells. Nano Letters, 2011; 11 (3): 1358 DOI: 10.1021/nl104528s
  2. Dorota Bartczak, Tilman Sanchez-Elsner, Fethi Louafi, Timothy M. Millar, Antonios G. Kanaras. Receptor-Mediated Interactions between Colloidal Gold Nanoparticles and Human Umbilical Vein Endothelial Cells. Small, 2011; 7 (3): 388 DOI: 10.1002/smll.201001816

Cite This Page:

University of Southampton. "Gold nanoparticles bring scientists closer to a treatment for cancer." ScienceDaily. ScienceDaily, 6 July 2011. <www.sciencedaily.com/releases/2011/07/110705071518.htm>.
University of Southampton. (2011, July 6). Gold nanoparticles bring scientists closer to a treatment for cancer. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2011/07/110705071518.htm
University of Southampton. "Gold nanoparticles bring scientists closer to a treatment for cancer." ScienceDaily. www.sciencedaily.com/releases/2011/07/110705071518.htm (accessed September 22, 2014).

Share This



More Matter & Energy News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: SpaceX Rocket Carries 3-D Printer to Space

Raw: SpaceX Rocket Carries 3-D Printer to Space

AP (Sep. 22, 2014) — A SpaceX Rocket launched from Cape Canaveral, carrying a custom-built 3-D printer into space. NASA envisions astronauts one day using the printer to make their own spare parts. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Thousands March in NYC Over Climate Change

Thousands March in NYC Over Climate Change

AP (Sep. 21, 2014) — Accompanied by drumbeats, wearing costumes and carrying signs, thousands of demonstrators filled the streets of Manhattan and other cities around the world on Sunday to urge policy makers to take action on climate change. (Sept. 21) Video provided by AP
Powered by NewsLook.com
What This MIT Sensor Could Mean For The Future Of Robotics

What This MIT Sensor Could Mean For The Future Of Robotics

Newsy (Sep. 20, 2014) — MIT researchers developed a light-based sensor that gives robots 100 times the sensitivity of a human finger, allowing for "unprecedented dexterity." Video provided by Newsy
Powered by NewsLook.com
MIT BioSuit A New Take On Traditional Spacesuits

MIT BioSuit A New Take On Traditional Spacesuits

Newsy (Sep. 19, 2014) — The MIT BioSuit could be an alternative to big, bulky traditional spacesuits, but the concept needs some work. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins