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New method used to detect 20 drugs in cow, goat and human milk

Date:
July 6, 2011
Source:
Plataforma SINC
Summary:
Researchers have developed a method that makes it possible to simultaneously detect 20 pharmaceutical products in cow, goat and human milk. The samples of the three types of milk studied showed that they all contain anti-inflammatories, although the largest number of drugs was found in whole cows' milk.
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A Spanish-Moroccan research team has developed a method that makes it possible to simultaneously detect 20 pharmaceutical products in cow, goat and human milk. The samples of the three types of milk studied showed that they all contain anti-inflammatories, although the largest number of drugs was found in whole cows' milk.

Up to 20 kinds of antibiotics, anti-inflammatories, antiseptics, lipid regulators, beta-blockers and hormones can be detected simultaneously in various kinds of milk, thanks to a new method developed by researchers at the universities of Jaén and Córdoba in Spain and the Abdelmalek Essaadi University in Morocco.

"We used this methodology to analyse 20 samples of cows' milk (fresh, whole, semi-skimmed, skimmed and powdered), goats' milk (whole and semi-skimmed) and breast milk from human volunteers, and we found that the drug content differs according to the type of milk," Evaristo Ballesteros, a researcher at the University of Jaén and the study director, said.

The highest number of pharmacological substances was found in whole cows' milk, particularly niflumic acid, mefenamic acid and ketoprofen (three anti-inflammatory drugs) and the hormone 17-beta-estradiol. Niflumic acid was also found in goats' milk, along with flunixin.

The human milk analysed, meanwhile, also contained anti-inflammatory drugs (such as ibuprofen and naproxen), as well as the antiseptic triclosan and some hormones, such as 17-alfa-ethinyl estradiol, 17-beta-estradiol and estrone.

The researchers acknowledge that the results of the study, published in the Journal of Agricultural and Food Chemistry, cannot be extrapolated to all kinds of milk in general due to the small number of samples analysed, but they say it does confirm the validity of the method. The technique uses a "system of continuous extraction of substances in solid phase" and classifies them using "gas chromatography-mass spectrometry."

"The validation results clearly show that this method is the most sensitive and one of the most selective described to date in the scientific literature," explains Ballesteros. "It is also highly precise and exact, with short analysis times (around 30 minutes)."

The scientists believe the new methodology will help to provide a more effective way of determining the presence of these kinds of contaminants in milk or other products. Food quality control laboratories could use this new tool to detect these drugs before they enter the food chain.

"This would raise consumers' awareness and give them the knowledge that food, aside from its good organoleptic properties and good value, is also harmless, pure, genuine, beneficial to health and free of toxic residues," the researcher concludes.


Story Source:

The above story is based on materials provided by Plataforma SINC. Note: Materials may be edited for content and length.


Journal Reference:

  1. Beatriz Jurado-Sánchez, Evaristo Ballesteros, Mercedes Gallego. Gas Chromatographic Determination ofN-Nitrosamines, Aromatic Amines, and Melamine in Milk and Dairy Products Using an Automatic Solid-Phase Extraction System. Journal of Agricultural and Food Chemistry, 2011; 110603135313021 DOI: 10.1021/jf2013919

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Plataforma SINC. "New method used to detect 20 drugs in cow, goat and human milk." ScienceDaily. ScienceDaily, 6 July 2011. <www.sciencedaily.com/releases/2011/07/110705081113.htm>.
Plataforma SINC. (2011, July 6). New method used to detect 20 drugs in cow, goat and human milk. ScienceDaily. Retrieved May 30, 2015 from www.sciencedaily.com/releases/2011/07/110705081113.htm
Plataforma SINC. "New method used to detect 20 drugs in cow, goat and human milk." ScienceDaily. www.sciencedaily.com/releases/2011/07/110705081113.htm (accessed May 30, 2015).

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