Featured Research

from universities, journals, and other organizations

Benefit of PET in malignant melanoma is unclear

Date:
July 20, 2011
Source:
Institute for Quality and Efficiency in Health Care
Summary:
The relevance of positron emission tomography alone or in combination with computed tomography in patients with malignant melanoma cannot be currently assessed, as the studies presently available do not allow robust conclusions.

The relevance of positron emission tomography (PET) alone or in combination with computed tomography (CT) in patients with malignant melanoma cannot be currently assessed due to a lack of meaningful studies.

This is the result of a final report published by the German Institute for Quality and Efficiency in Health Care (IQWiG) on 20 July 2011.

Hidden metastases are often detected too late

Malignant melanoma ("black skin cancer") may follow very different courses. In most patients the tumour can be removed completely by minor surgery. However, on first diagnosis some patients already have hidden metastases that are often detected only at a later stage. Many health care experts hope that an examination with PET or PET/CT, alone or in combination with other methods, can help detect hidden metastases as early as the first diagnosis. In addition, they hope that in follow-up examinations, PET or PET/CT can detect tumour recurrence earlier. The information obtained should then enable doctors to provide better treatment recommendations for patients.

Benefit for patients is crucial

IQWiG therefore searched the international scientific literature for studies investigating the impact of PET or PET/CT on health aspects directly relevant to patients. For example, the test results could help treat patients with further useful therapies at an earlier stage, or the results could help spare patients unnecessary treatment. However, the search for such studies was unsuccessful, so that the question as to the benefit of PET or PET/CT remained unanswered.

Reliability not clear

In addition, IQWiG searched for studies in which the diagnostic accuracy of PET or PET/CT was compared to other test methods. This investigates the question as to how often a PET test produces wrong results. The test should on the one hand overlook metastases as rarely as possible, but on the other, should not raise unjustified suspicions. Although a total of 17 diagnosis accuracy studies were found, the diagnostic accuracy of PET or PET/CT varied greatly in these studies. A comparison of PET or PET/CT with other technologies (e.g. CT alone) was investigated in only 2 studies, so that no general conclusions can be drawn for this question either.

Studies of high methodological quality are therefore urgently needed to investigate the benefit of PET or PET/CT in patients with malignant melanoma.

An overview of the background, methods and further results of the final report is provided in the following executive summary.


Story Source:

The above story is based on materials provided by Institute for Quality and Efficiency in Health Care. Note: Materials may be edited for content and length.


Cite This Page:

Institute for Quality and Efficiency in Health Care. "Benefit of PET in malignant melanoma is unclear." ScienceDaily. ScienceDaily, 20 July 2011. <www.sciencedaily.com/releases/2011/07/110720121903.htm>.
Institute for Quality and Efficiency in Health Care. (2011, July 20). Benefit of PET in malignant melanoma is unclear. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2011/07/110720121903.htm
Institute for Quality and Efficiency in Health Care. "Benefit of PET in malignant melanoma is unclear." ScienceDaily. www.sciencedaily.com/releases/2011/07/110720121903.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins