Featured Research

from universities, journals, and other organizations

Fault in immune memory causes atopic eczema and psoriasis, study finds

Date:
July 25, 2011
Source:
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health
Summary:
Scientists believe they have discovered the causes of atopic eczema and psoriasis. Findings from a new study show that both diseases are caused by an impaired immunological memory.

Psoriasis. Scientists believe the have discovered the causes of atopic eczema and psoriasis.
Credit: © quayside / Fotolia

Scientists from the Centre for Allergy and Environment in Munich (ZAUM), the Helmholtz Zentrum München and the Technische Universität München believe the have discovered the causes of atopic eczema and psoriasis. The results of the studies have been published in the New England Journal of Medicine.

Related Articles


The findings of a research study conducted by Stefanie and Kilian Eyerich show that both diseases are caused by an impaired immunological memory.

The couple, who are engaged in research at the Helmholtz Zentrum München and the Department of Dermatology and Allergology Biederstein, Technische Universität München (TUM), based their study on a rare group of patients who suffer from both diseases. As their results show, the T-cells of the immune system in the skin activate an inflammatory programme that causes either atopic eczema or psoriasis. Professor Ring, co-author and Director of Department of Dermatology and Allergology Biederstein believes that "this study highlights the critical role of T-cells in psoriasis."

The scientists now aim to find out which T-cell molecules are responsible for triggering these diseases. "Clearly, future therapy strategies should focus on the impairment of the immunological memory," says Professor Carsten Schmidt-Weber, Director of ZAUM.

  • T-cells together with the B-cells form the body's immunological memory. They initiate an immune response when they recognice substances that are foreign to the body.
  • In the case of atopic eczema / neurodermatitis, the T-cells recognise substances that trigger an immune response: these include components of pollen, house-dust mites and also bacteria. In the case of psoriasis, it remains unclear which molecules are responsible for the response.

Story Source:

The above story is based on materials provided by Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Stefanie Eyerich, Anna T. Onken, Stephan Weidinger, Andre Franke, Francesca Nasorri, Davide Pennino, Martine Grosber, Florian Pfab, Carsten B. Schmidt-Weber, Martin Mempel, Ruediger Hein, Johannes Ring, Andrea Cavani, Kilian Eyerich. Mutual Antagonism of T Cells Causing Psoriasis and Atopic Eczema. New England Journal of Medicine, 2011; 365 (3): 231 DOI: 10.1056/NEJMoa1104200

Cite This Page:

Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. "Fault in immune memory causes atopic eczema and psoriasis, study finds." ScienceDaily. ScienceDaily, 25 July 2011. <www.sciencedaily.com/releases/2011/07/110722130250.htm>.
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. (2011, July 25). Fault in immune memory causes atopic eczema and psoriasis, study finds. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2011/07/110722130250.htm
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. "Fault in immune memory causes atopic eczema and psoriasis, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/07/110722130250.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) — An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins