Featured Research

from universities, journals, and other organizations

How testosterone protects against inflammation

Date:
July 26, 2011
Source:
Friedrich Schiller University Jena
Summary:
Pharmacists have shown that cells from men and women react in a different manner to inflammatory stimuli. They found that in male cells the enzyme phospholipase D is less active than in the female ones. Based on these findings, the pharmacists concluded that the male sex hormones play a key role in the modulation of the immune response.

Dr. Carlo Pergola found out, that cells from men and women react in a different manner to inflammatory stimuli.
Credit: Jan-Peter Kasper/FSU

Pharmacists have shown that cells from men and women react in a different manner to inflammatory stimuli. They found that in male cells the enzyme phospholipase D is less active than in the female ones. Based on these findings, the pharmacists concluded that the male sex hormones play a key role in the modulation of the immune response.

Related Articles


It’s all down to the testosterone: men are usually more muscular than women, they have deeper voices and more body hair. And – men are less susceptible to inflammatory diseases and allergies than women. This is also due to the male sex hormones as pharmacists at the Friedrich Schiller University Jena (Germany) have shown in a recent study.

“It is mostly women who are affected by diseases like rheumatoid arthritis, psoriasis or asthma“, Professor Dr. Oliver Werz from the Jena University explains. Although this is a fact known for some time, the reasons for these differences are largely unknown. As the Jena Professor for pharmaceutical and medical chemistry and his team have revealed now, sexual hormones play an important role in this. The researchers report about this in the current edition of the scientific journal FASEB Journal.

“In a series of analyses we have shown that cells from men and women react in a different manner to inflammatory stimuli,” Dr. Carlo Pergola from the Institute of Pharmacy of University Jena explains. Thus, certain immune cells of women produced nearly twice as many pro-inflammatory substances than those of men. Together with colleagues from Tόbingen (Germany), Stockholm (Sweden) and Naples (Italy) the Jena researchers pursued the molecular basis for these differences and published their findings in their current study. To this aim, they isolated immune cells of male and female donors and analyzed in test tubes the activity of the enzymes responsible for the production of pro-inflammatory substances. They found that in male cells the enzyme phospholipase D is less active than in the female ones. “Interestingly, the activity of the enzyme is reduced after treatment with testosterone also in the female immune cells“, Dr. Pergola defines a crucial result.

Based on these findings, the Jena pharmacists concluded that the male sex hormones play a key role in the modulation of the immune response. This would also explain another phenomenon that has been previously noticed, that is, testosterone can protect men from arteriosclerosis.

Most importantly, the new knowledge should be taken into account in the assessment of new therapies and drugs for inflammatory diseases, Professor Werz stresses. “New therapies are usually still more often being tested on male volunteers or patients.“ But the Jena study indicates now that the results derived from male subjects cannot be immediately transcribed to women. On the contrary, a ‘customized’ therapy for men and women would be important.


Story Source:

The above story is based on materials provided by Friedrich Schiller University Jena. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. Pergola, A. Rogge, G. Dodt, H. Northoff, C. Weinigel, D. Barz, O. Radmark, L. Sautebin, O. Werz. Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes. The FASEB Journal, 2011; DOI: 10.1096/fj.11-182758

Cite This Page:

Friedrich Schiller University Jena. "How testosterone protects against inflammation." ScienceDaily. ScienceDaily, 26 July 2011. <www.sciencedaily.com/releases/2011/07/110726093146.htm>.
Friedrich Schiller University Jena. (2011, July 26). How testosterone protects against inflammation. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2011/07/110726093146.htm
Friedrich Schiller University Jena. "How testosterone protects against inflammation." ScienceDaily. www.sciencedaily.com/releases/2011/07/110726093146.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) — NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) — A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Microsoft Launches Fitness Band After Accidental Reveal

Microsoft Launches Fitness Band After Accidental Reveal

Newsy (Oct. 30, 2014) — Microsoft accidentally revealed its upcoming fitness band on Wednesday, so the company went ahead and announced it. Video provided by Newsy
Powered by NewsLook.com
Bracing to Meet a Killer: Aid Workers Prep for Ebola in Geneva

Bracing to Meet a Killer: Aid Workers Prep for Ebola in Geneva

AFP (Oct. 30, 2014) — At the International Federation of Red Cross and Red Crescent Societies, around 30 doctors, nurses, lab technicians and water and sanitation workers are gathered for a crash-course in how to safely deal Ebola. Duration: 01:31 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins