Featured Research

from universities, journals, and other organizations

Newly developed molecule tested as a delivery vehicle to image and kill brain tumors

Date:
August 4, 2011
Source:
Virginia Commonwealth University
Summary:
A single compound with dual function -- the ability to deliver a diagnostic and therapeutic agent -- may one day be used to enhance the diagnosis, imaging and treatment of brain tumors, according to new research.

A single compound with dual function -- the ability to deliver a diagnostic and therapeutic agent -- may one day be used to enhance the diagnosis, imaging and treatment of brain tumors, according to findings from Virginia Commonwealth University and Virginia Tech.

Glioblastomas are the most common and aggressive brain tumor in humans, with a high rate of relapse. These tumor cells often extend beyond the well-defined tumor margins making it extremely difficult for clinicians and radiologists to visualize with current imaging techniques. Researchers have been investigating enhanced methods of attacking these cells in order to possibly delay or prevent brain tumor relapse.

In a study published in the August issue of the journal Radiology, the research team led by Panos Fatouros, Ph.D., a former professor and chair of the Division of Radiation Physics and Biology in the VCU School of Medicine who retired in 2010, demonstrated that a nanoparticle containing an MRI diagnostic agent can effectively be imaged within the brain tumor and provide radiation therapy in an animal model.

The nanoparticle filled with gadolinium, a sensitive MRI contrast agent for imaging, and coupled with radioactive lutetium 177 to deliver brachytherapy, is known as a theranostic agent -- a single compound capable of delivering simultaneously effective treatment and imaging. The lutetium 177 is attached to the outside of the carbon cage of the nanoparticle.

"We believe the clustering properties of this nanoplatform prolong its retention within the tumor, thereby allowing a higher radiation dose to be delivered locally," said Michael Shultz, Ph.D., a research fellow in Fatouros' lab in the Department of Radiology in the VCU School of Medicine.

"This theranostic agent could potentially provide critical data about tumor response to therapy by means of longitudinal imaging without further contrast administration," said Fatouros.

A nanoparticle called a functionalized metallofullerene (fMF), also known as a "buckyball," served as the basis of this work and was created by study collaborator, Harry Dorn, Ph.D., a chemistry professor at Virginia Tech, and his team. In 1999, Dorn and his colleagues were able to encapsulate rare earth metals in the hollow interior of these nanoparticles that can easily be recognized by MRI techniques.

"Although this is a limited animal study, it shows great promise and hopefully this metallofullerene platform will be extended to humans," said Dorn.

Fatouros, who is the corresponding author on the study, Shultz and Dorn collaborated with John D. Wilson, Ph.D., associate professor in the VCU Department of Radiology; Christine E. Fuller, M.D., professor and director of neuropathology and autopsy pathology at VCU; and Jianyuan "Jason" Zhang, a graduate student in chemistry at Virginia Tech from Beijing, China.

The study was funded by grants to Fatouros from the National Institutes of Health's National Cancer Institute, and to Dorn from the National Science Foundation.


Story Source:

The above story is based on materials provided by Virginia Commonwealth University. Note: Materials may be edited for content and length.


Journal Reference:

  1. John D. Wilson, Christine E. Fuller, Jianyuan Zhang, Harry C. Dorn, Panos P. Fatouros. Metallofullerene-based Nanoplatform for Brain Tumor Brachytherapy and Longitudinal Imaging in a Murine Orthotopic Xenograft Model. Radiology, 2011; DOI: 10.1148/radiol.11102569

Cite This Page:

Virginia Commonwealth University. "Newly developed molecule tested as a delivery vehicle to image and kill brain tumors." ScienceDaily. ScienceDaily, 4 August 2011. <www.sciencedaily.com/releases/2011/08/110803174753.htm>.
Virginia Commonwealth University. (2011, August 4). Newly developed molecule tested as a delivery vehicle to image and kill brain tumors. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2011/08/110803174753.htm
Virginia Commonwealth University. "Newly developed molecule tested as a delivery vehicle to image and kill brain tumors." ScienceDaily. www.sciencedaily.com/releases/2011/08/110803174753.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins