Featured Research

from universities, journals, and other organizations

Differences in metabolic disease markers in healthy and obese 7-to-9-year-olds identified

Date:
August 25, 2011
Source:
Louisiana State University Health Sciences Center
Summary:
Obese 7-to-9-year-old children had nearly three times the liver fat and almost double the belly fat of their non-obese counterparts and insulin resistance was more than double and insulin sensitivity less than half respectively, according to a new study. The study is among the first to use a combination of advanced measurements in healthy obese and non-obese children in this age group prior to entering puberty.

Research led by Dr. Melinda Sothern, Professor of Public Health and Jim Finks Endowed Chair in Health Promotion at LSU Health Sciences Center New Orleans, has found that obese 7-9-year-old children had nearly three times the liver fat and almost double the belly fat of their nonobese counterparts and that insulin resistance was more than double and insulin sensitivity less than half respectively. The study is the first to use a combination of advanced measurements in healthy obese and nonobese children in this age group prior to entering puberty.

Related Articles


The findings are detailed in the journal, Obesity, online August 25, 2011.

"The amount of body fat as well as its location, particularly in the liver, appears to play a critical role in disease development," notes LSUHSC's Dr. Melinda Sothern. "The substantial variation in biomarkers we observed in these young children suggests that obesity in this age group may disrupt normal metabolism, impairing glucose tolerance and increasing the risk for Type 2 diabetes later in life."

The researchers studied 123 children, ages 7-9, recruited from southeast Louisiana. By BMI z-score thresholds, 23.6% of the children were obese. Although a clear definition for the metabolic syndrome in children and adolescents has not yet been established, by one set of proposed criteria, 16% of participants met the definition, and 8% met the criteria by another definition.

"Our data confirm that healthy obese young children may already be predisposed to the development of metabolic disease as has been demonstrated in adult populations," said Dr. Sothern. "Our findings highlight the importance of interventions to prevent and manage obesity very early in life and suggest this is a possible means of reducing metabolic disease risk and combating the increasing prevalence of Type 2 diabetes."

Over the past 30 years, the prevalence of obesity has increased considerably. Although a recent national report indicates a leveling off of this trend, a significant portion of the pediatric population remains obese and at risk for developing metabolic diseases, particularly those related to carbohydrate metabolism. Some regions, especially areas with traditionally higher obesity prevalence rates, however, may not mirror national estimates.

The research team also included Drs. Julia Volaufova, William Cefalu, Stuart Chalew, Stewart Gordon, and Arlette Soros as well as Brian Bennett at LSU Health Sciences Center; Drs. Eric Ravussin, and Steve Smith at LSU's Pennington Biomedical Research Center, as well as Dr. Enette Larson-Meyer at the University of Wyoming; Dr. Bradley Newcomer at the University of Alabama at Birmingham; and Dr. Michael Goran at the University of Southern California.

The research was supported by grants from the National Institutes of Health's Eunice Kennedy Shriver National Institute of Child Health and Human Development and National Institute of Diabetes and Digestive and Kidney Disorders.


Story Source:

The above story is based on materials provided by Louisiana State University Health Sciences Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Brian Bennett, D. Enette Larson-Meyer, Eric Ravussin, Julia Volaufova, Arlette Soros, William T. Cefalu, Stuart Chalew, Stewart Gordon, Steven R. Smith, Bradley R. Newcomer, Michael Goran, Melinda Sothern. Impaired Insulin Sensitivity and Elevated Ectopic Fat in Healthy Obese vs. Nonobese Prepubertal Children. Obesity, 2011; DOI: 10.1038/oby.2011.264

Cite This Page:

Louisiana State University Health Sciences Center. "Differences in metabolic disease markers in healthy and obese 7-to-9-year-olds identified." ScienceDaily. ScienceDaily, 25 August 2011. <www.sciencedaily.com/releases/2011/08/110825102235.htm>.
Louisiana State University Health Sciences Center. (2011, August 25). Differences in metabolic disease markers in healthy and obese 7-to-9-year-olds identified. ScienceDaily. Retrieved November 29, 2014 from www.sciencedaily.com/releases/2011/08/110825102235.htm
Louisiana State University Health Sciences Center. "Differences in metabolic disease markers in healthy and obese 7-to-9-year-olds identified." ScienceDaily. www.sciencedaily.com/releases/2011/08/110825102235.htm (accessed November 29, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins