Featured Research

from universities, journals, and other organizations

Medication used to reduce heart rate also reduces heart volume in patients with cardiac insufficiency, study finds

Date:
August 29, 2011
Source:
Montreal Heart Institute
Summary:
Researchers have presented results of an analysis demonstrating that ivabradine, a medication used to reduce heart rate, also reduces heart volume (left ventricle) among patients with cardiac insufficiency.

As guest speaker at the European Society of Cardiology's Congress 2011 in Paris, Dr. Jean-Claude Tardif, Director of the Montreal Heart Institute's Research Centre and professor of medicine at the Universitι de Montrιal,  presented the results of an analysis demonstrating that ivabradine, a medication used to reduce heart rate, also reduces heart volume (left ventricle) among patients with cardiac insufficiency.

In 2010, the findings of the SHIFT (Systolic Heart failure treatment with the If inhibitor Ivabradine Trial) clinical trial were published in the scientific journal The Lancet. These findings demonstrated that reducing heart rate with ivabradine also led to a significant reduction in mortality and hospitalizations among patients with left cardiac insufficiency. The objective of the sub-study was to assess the effects of ivabradine responsible for this benefit.

To achieve this, Dr. Tardif and his team compared the echocardiographies of 411 patients with cardiac insufficiency randomly assigned to ivabradine or a placebo before and after eight months of treatment. After analyzing the results, they discovered a significant reduction in heart volume (left ventricle) among the patients taking ivabradine compared to the placebo group. They also noted an improvement in the ejection function of the left ventricle among patients treated with ivabradine. This constitutes a remarkable advance since patients with cardiac insufficiency are at risk of serious problems as the disease progresses.

Left cardiac insufficiency is characterized by the inability of the heart to properly execute its pumping function, which makes it possible to effectively eject the blood toward the aorta. This inability gives rise to compensating mechanisms such as increased heart rate, dilation of the left ventricle, and a thickening of the heart muscle. "In spite of current therapies, cardiac insufficiency, in the last few decades, has been a leading public health concern associated with significant mortality and morbidity," said Dr. Tardif. "The reduction in heart volume and the improved left ventricle contraction observed with ivabradine hold a great deal of promise. This is a further step toward a new approach to the treatment of cardiac insufficiency."

Subsequent to the 2005 INITIATIVE study directed by Dr. Jean-Claude Tardif, ivabradine was eventually made available in 80 countries. Ivabradine is not yet available in Canada, however.


Story Source:

The above story is based on materials provided by Montreal Heart Institute. Note: Materials may be edited for content and length.


Cite This Page:

Montreal Heart Institute. "Medication used to reduce heart rate also reduces heart volume in patients with cardiac insufficiency, study finds." ScienceDaily. ScienceDaily, 29 August 2011. <www.sciencedaily.com/releases/2011/08/110829114600.htm>.
Montreal Heart Institute. (2011, August 29). Medication used to reduce heart rate also reduces heart volume in patients with cardiac insufficiency, study finds. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2011/08/110829114600.htm
Montreal Heart Institute. "Medication used to reduce heart rate also reduces heart volume in patients with cardiac insufficiency, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/08/110829114600.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) — Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) — NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) — In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) — The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins