Featured Research

from universities, journals, and other organizations

Twenty-three microRNAs linked to laryngeal cancer

Date:
September 13, 2011
Source:
Henry Ford Health System
Summary:
A new study has identified 23 microRNAs for laryngeal cancer, 15 of which had yet to be reported in head and neck cancer. The researchers say the discovery could yield new insight into what causes certain cells to grow and become cancerous tumors in the voice box.

A Henry Ford Hospital study has identified 23 microRNAs for laryngeal cancer, a discovery that could yield new insight into what causes certain cells to grow and become cancerous tumors in the voice box.

The role of microRNA (miRNA), the small, non-coding RNA molecules that regulate human genes, has recently come into greater focus as researchers continue to understand the cellular mechanics of cancer development, says Kang Mei Chen, M.D., the study's lead author.

"While they may be small, miRNAs are no longer being viewed as just molecular noise," says Dr. Chen, a research investigator in the Department of Otolaryngology -- Head & Neck Surgery at Henry Ford Hospital.

"We now recognize miRNAs as bigger players with increasing prominence in theories about cancer."

Findings from the Henry Ford study -- supported by a NIH grant -- was presented on Sept. 13 in San Francisco at the American Academy of Otolaryngology-Head & Neck Surgery Foundation Annual Meeting.

MiRNA may help cancer researchers unravel the complexities of what happens at the genomic level of cell evolution. It's estimated that there are at least 800 human miRNAs.

Since miRNAs are differentially expressed in various types of cancers compared with noncancerous tissues, researchers believe that they may play a crucial role in the production or formation of tumors.

"By gaining insight into laryngeal cancer, it gives us another level to understand what goes wrong and when cells decide to embark on a tumor genesis journey. From there, it's possible for researchers to look at how to control cancer growth and improve treatment," says co-author Maria J. Worsham, Ph.D., director of research in the Department of Otolaryngology-Head & Neck Surgery at Henry Ford.

The goal of the Henry Ford study was to discover miRNAs specific to laryngeal squamous cell carcinoma -- a form of head and neck cancer that starts in the voice box.

Led by Dr. Chen, the researchers performed global miRNA profiling on stored laryngeal squamous cell carcinoma samples, as well as non-cancerous tissue samples from the larynx.

The team then used quantitative real-time polymerase chain reaction -- a fast and inexpensive technique used to copy small segments of DNA -- to verify miRNAs in the laryngeal cancer samples.

Of the 800 human miRNAs, 23 were found to be different between the cancerous and normal laryngeal tissue samples.

Among the 23 miRNAs tied to laryngeal cancer through the Henry Ford study, 15 had yet to be reported in head and neck cancer.

With the field narrowed to 23 miRNAs in laryngeal cancer, it presents researchers with the opportunity to quantify each piece of RNA and further study miRNAs in head and neck cancer, notes Dr. Chen.

The NIH-funded head and neck squamous carcinoma cohort for Detroit, with over 1,000 primary patients, includes more than 200 laryngeal sites, giving Henry Ford researchers the opportunity to look at miRNA expression in a larger group of laryngeal cancers as well as in other head and neck cancer sites.

Along with Drs. Chen and Worsham, study co-authors from Henry Ford are Josena K. Stephen, M.D.; Shaleta Havard; Veena Shah, M.D.; Glendon Gardner, M.D.; and Vanessa G. Schweitzer, M.D.

Research Support: NIH grant R01DE15990.


Story Source:

The above story is based on materials provided by Henry Ford Health System. Note: Materials may be edited for content and length.


Cite This Page:

Henry Ford Health System. "Twenty-three microRNAs linked to laryngeal cancer." ScienceDaily. ScienceDaily, 13 September 2011. <www.sciencedaily.com/releases/2011/09/110913133218.htm>.
Henry Ford Health System. (2011, September 13). Twenty-three microRNAs linked to laryngeal cancer. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2011/09/110913133218.htm
Henry Ford Health System. "Twenty-three microRNAs linked to laryngeal cancer." ScienceDaily. www.sciencedaily.com/releases/2011/09/110913133218.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins