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Combination therapy beneficial for head and neck skin carcinomas, study suggests

Date:
October 4, 2011
Source:
University of North Carolina School of Medicine
Summary:
Patients who have high-risk non-melanoma skin carcinomas of the head and neck may benefit from concomitant radiotherapy and chemotherapy, according to a new study. Their study is the first to report on multiple patients with these skin carcinomas treated simultaneously with radio- and chemotherapy.

Patients who have high-risk non-melanoma skin carcinomas of the head and neck may benefit from concomitant radiotherapy and chemotherapy, according to a UNC-led study. Their study is the first to report on multiple patients with these skin carcinomas treated simultaneously with radio-and chemotherapy.

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Scientists with the UNC Lineberger Comprehensive Cancer Center reported their findings in the Sept. 26, 2011 online issue of the International Journal of Surgery.

Non-melanoma skin carcinoma (NMSC) is the most common malignancy worldwide with an incidence of over 1.3 million in the United States. These cancers occur in anatomic areas subject to frequent sun exposure such as the head and neck. Most of these cancers can be cured with local treatments such as surgery or radiation. Some cancers, however, are high risk, meaning they are biologically and clinically aggressive, and require more treatment, with characteristics such as large tumor size, regional nodal involvement or recurrent disease.

Because this patient population is small, there are limited data on optimal care for these cancers. Neil Hayes, MD, MPH, associate professor of medicine and senior author, explains, " Combination therapy is often used to treat other types of cancer, but not non-melanoma skin carcinoma. Our study provides the first evidence that this approach might be effective for this high-risk type of cancer. Skin cancer incidence is increasing worldwide, so having a more comprehensive and effective treatment regimen will help the patients with the most aggressive forms of this disease."

Scientists with the UNC Head and Neck Oncology Program conducted a retrospective study of 45 patients treated for NMSC with either concomitant radio- and chemotherapy or radiotherapy alone. They found that those treated with the combination therapy relapsed at rates that approximately half of those of patients who received radiation when accounting for other risk factors. While the relatively small size of the study does not definitively prove such a large benefit, it does offer strong support that this treatment approach should receive attention in future studies.

Hayes concludes, "This study provides preliminary data on the feasibility of combining chemotherapy concomitantly with radiotherapy and further studies are needed to fully assess toxicity and better define subsets of patients who might benefit from combined modality treatment."

Other UNC authors are Nirav Dhruva, MD; Farhad Ardeshirpour, MD; Joel Tepper, MD; Carol Shores, MD, PhD; Julian Rosenman, MD, PhD; William Shockley, MD; and Michele Hayward, RD.


Story Source:

The above story is based on materials provided by University of North Carolina School of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

University of North Carolina School of Medicine. "Combination therapy beneficial for head and neck skin carcinomas, study suggests." ScienceDaily. ScienceDaily, 4 October 2011. <www.sciencedaily.com/releases/2011/10/111004121258.htm>.
University of North Carolina School of Medicine. (2011, October 4). Combination therapy beneficial for head and neck skin carcinomas, study suggests. ScienceDaily. Retrieved November 20, 2014 from www.sciencedaily.com/releases/2011/10/111004121258.htm
University of North Carolina School of Medicine. "Combination therapy beneficial for head and neck skin carcinomas, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/10/111004121258.htm (accessed November 20, 2014).

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