Featured Research

from universities, journals, and other organizations

Sociability may depend upon brain cells generated in adolescence

Date:
October 5, 2011
Source:
Yale University
Summary:
Mice become profoundly anti-social when the creation of new brain cells is interrupted in adolescence, a surprising finding that may help researchers understand schizophrenia and other mental disorders, researchers report.

The social behavior of mice seems to be dictated by creation of new neurons in adolescence.
Credit: Courtesy of Yale University

Mice become profoundly anti-social when the creation of new brain cells is interrupted in adolescence, a surprising finding that may help researchers understand schizophrenia and other mental disorders, Yale researchers report.

Related Articles


When the same process is interrupted in adults, no such behavioral changes were noted, according to research published in the Oct. 4 issue of the journal Neuroscience.

"This has important implications in understanding social development at the molecular level," said Arie Kaffman, assistant professor of psychiatry and senior author of the study.

Scientists have known for quite some time that new brain cells are continually generated in specific brain regions after birth. This process, called neurogenesis, occurs at a significantly greater rate during childhood and adolescence than in adulthood, yet most research has focused upon the function of these neurons in older brains.

The Yale team decided to explore the function of these new brain cells in mice of different ages. Normal adult mice tend to spend a lot of time exploring and interacting with unfamiliar mice. However, adult mice that had neurogenesis blocked during adolescence showed no interest in exploring other adult mice and even evaded attempts made by other mice to engage in social behavior.

"These mice acted like they did not recognize other mice as mice," Kaffman said.

Blocking adult neurogenesis had no effect on social behavior, suggesting that brain cells generated during adolescence make a very different contribution to brain function and behavior in adulthood, note the scientists.

Intriguingly, schizophrenics have a deficit in generating new neurons in the hippocampus, one of the brain areas where new neurons are created. Given that symptoms of schizophrenia first emerge in adolescence, it is possible that deficits in generating new neurons during adolescence or even in childhood holds new insights into the development of some of the social and cognitive deficits seen in this illness, Kaffman said.

Other Yale authors include Lan Wei and Ronald S. Duman.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Sociability may depend upon brain cells generated in adolescence." ScienceDaily. ScienceDaily, 5 October 2011. <www.sciencedaily.com/releases/2011/10/111004180115.htm>.
Yale University. (2011, October 5). Sociability may depend upon brain cells generated in adolescence. ScienceDaily. Retrieved January 29, 2015 from www.sciencedaily.com/releases/2011/10/111004180115.htm
Yale University. "Sociability may depend upon brain cells generated in adolescence." ScienceDaily. www.sciencedaily.com/releases/2011/10/111004180115.htm (accessed January 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, January 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Malnutrition on the Rise as Violence Flares in C. Africa

Malnutrition on the Rise as Violence Flares in C. Africa

AFP (Jan. 28, 2015) Violence can flare up at any moment in Bambari with only a bridge separating Muslims and Christians. Malnutrition is on the rise and lack of water means simple cooking fires threaten to destroy makeshift camps where people are living. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Media Criticizing Parents For Not Vaccinating Children

Media Criticizing Parents For Not Vaccinating Children

Newsy (Jan. 28, 2015) As the Disneyland measles outbreak continues to spread, the media says parents who choose not to vaccinate their children are part of the cause. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins