Featured Research

from universities, journals, and other organizations

Biochemists identify how tissue cells detect and perfect

Date:
October 7, 2011
Source:
University of Bristol
Summary:
Scientists have discovered how cells detect tissue damage and modify their repair properties accordingly. The findings could open up new opportunities for improving tissue repair in patients following illness or surgery.

Scientists have discovered how cells detect tissue damage and modify their repair properties accordingly. The findings, published October 6 in the journal Developmental Cell, could open up new opportunities for improving tissue repair in patients following illness or surgery.

The Wellcome Trust-funded study, led by biochemists at the University of Bristol, examined the signalling process in damaged tissue cells and identified the cellular mechanisms responsible for activating effective repair.

In healthy adults the majority of tissue cells lie dormant unless challenged by wounding, at which point they sense a change in the molecular environment. Plasma leaking from damaged blood vessels and causes fibroblast cells to migrate into the damaged tissue, contract the wound, and plug the gap by depositing a substance such as collagen, which provides the structural support.

Dr Mark Bass, lead author and Research Fellow in the University's School of Biochemistry, said: "Each of these processes requires the turnover of cellular adhesions, and the challenge has been to determine how cells detect tissue damage and modify their adhesive properties accordingly."

Using atomic force microscopy, the team were able to determine how a molecule sensor, syndecan-4, triggers the uptake and redeployment of adhesive molecules. This novel signalling pathway causes fibroblasts and keratinocytes to migrate in response to the changing tissue architecture and follow the matrix fibres that make up the skin. Such linear migration towards a damage signal allows the cells to arrive at the wound far more efficiently than if activated cells searched randomly about the tissue, and results in a very efficient healing response.

Dr Bass added: "We find that this signalling cascade is essential for efficient healing, this opens up considerable opportunities for improving tissue repair in patients."

The Wellcome Trust-funded study, entitled 'A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis' by Dr Mark Bass is published in the journal Developmental Cell.


Story Source:

The above story is based on materials provided by University of Bristol. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mark D. Bass, Rosalind C. Williamson, Robert D. Nunan, Jonathan D. Humphries, Adam Byron, Mark R. Morgan, Paul Martin, Martin J. Humphries. A Syndecan-4 Hair Trigger Initiates Wound Healing through Caveolin- and RhoG-Regulated Integrin Endocytosis. Developmental Cell, 06 October 2011 DOI: 10.1016/j.devcel.2011.08.007

Cite This Page:

University of Bristol. "Biochemists identify how tissue cells detect and perfect." ScienceDaily. ScienceDaily, 7 October 2011. <www.sciencedaily.com/releases/2011/10/111006125404.htm>.
University of Bristol. (2011, October 7). Biochemists identify how tissue cells detect and perfect. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2011/10/111006125404.htm
University of Bristol. "Biochemists identify how tissue cells detect and perfect." ScienceDaily. www.sciencedaily.com/releases/2011/10/111006125404.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins