Featured Research

from universities, journals, and other organizations

A safe vaccination for Alzheimer's disease?

Date:
October 11, 2011
Source:
INSERM (Institut national de la santé et de la recherche médicale)
Summary:
Genetic factors influence the immune response to vaccinations for Alzheimer's disease, which are among the most promising avenues of treatment for the illness. Using a mice model, these factors were studied.

The research shows that in addition to the major histocompatibility complex (MHC) molecules, which present the antigen vaccine to the immune cells, genetic factors, that control some immune cells, influence the quality of response to vaccinations. The results could make it possible to prevent neuroinflammatory reactions, which are major obstacles preventing the use of the vaccination in humans.

This study has just been published in the Journal of Immunology. Since the beginning of the 2000s, research into Alzheimer's disease has partly focussed on studying a vaccination composed of amyloid-β peptide (Aß), the accumulation of which in the brain is thought to trigger the disease. Vaccinations with this peptide caused serious neuroinflammatory reactions in 6% of patients. To develop a safer and more effective treatment, it is therefore essential to understand the factors that influence the body's responses to peptide Aß.

The joint Inserm/UPMC research team, led by Pierre Aucouturier, with Cécile Toly-Ndour and Guillaume Dorothée, conducted its research on mice with different forms of major histocompatibility complex (MHC). The role of these molecules is to present the antigens to the immune cells and they have a wide genetic diversity, which could explain the different responses. Indeed, after vaccination with the peptide Aß, mice with different MHC had different immune cell reactions. Researchers then pushed their studies further. By expressing the MHC from one line of mice to another, they demonstrated that factors in independent from MHC, but related to the genetic background, have a massive influence on the anti-Aß response. They then proved that these factors involve a sub-population of white blood cells (regulatory T cells).

These results provide a new direction to orientate immune cells advantageously, thus improving the immunotherapeutic approach, which remains one of the major hopes in the fight against Alzheimer's. However, these observations made on mice still require validation on human patients.


Story Source:

The above story is based on materials provided by INSERM (Institut national de la santé et de la recherche médicale). Note: Materials may be edited for content and length.


Journal Reference:

  1. Cécile Toly-Ndour, Gabrielle Lui, Maria Manuel Nunes, Martine Bruley-Rosset, Pierre Aucouturier and Guillaume Dorothée. MHC-Independent Genetic Factors Control the Magnitude of CD4 T Cell Responses to Amyloid-ß Peptide in Mice through Regulatory T Cell-Mediated Inhibition. Journal of Immunology, September 26, 2011 DOI: 10.4049/​jimmunol.1003953

Cite This Page:

INSERM (Institut national de la santé et de la recherche médicale). "A safe vaccination for Alzheimer's disease?." ScienceDaily. ScienceDaily, 11 October 2011. <www.sciencedaily.com/releases/2011/10/111011121248.htm>.
INSERM (Institut national de la santé et de la recherche médicale). (2011, October 11). A safe vaccination for Alzheimer's disease?. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2011/10/111011121248.htm
INSERM (Institut national de la santé et de la recherche médicale). "A safe vaccination for Alzheimer's disease?." ScienceDaily. www.sciencedaily.com/releases/2011/10/111011121248.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) — A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) — Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) — The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) — A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins