Featured Research

from universities, journals, and other organizations

Developing new drugs made easier with method to track drugs in tissue

Date:
October 17, 2011
Source:
Lund University
Summary:
When a new drug is developed, the manufacturer must be able to show that it reaches its intended goal in the body's tissue, and only that goal. Such studies could be made easier with a new method.

When a new drug is developed, the manufacturer must be able to show that it reaches its intended goal in the body's tissue, and only that goal. Such studies could be made easier with a new method now established at Lund University in Sweden.

The method is a special type of mass spectrometry which can be used on drugs 'off the shelf', i.e. without any radioactive labelling which may change the behaviour of the drug. With this method, researchers György Marko-Varga and Thomas Fehniger have managed to create a molecular image of the drug in the tissue.

The tissue examined comes from biopsies from the lungs of patients with lung cancer and chronic obstructive lung disease (COPD), who have inhaled a drug to dilate the airways. The examination showed the precise spatial distribution of the drug within the tissue. The results are based on an analysis of 3 000 measurement points of 0.01 mm2 in each biopsy sample.

"When you want to register a new drug, you must be able to both explain its exact mechanisms of action and show that it is effective and safe. In order to avoid side-effects, the drug should reach only the cells for which it is intended. Our new technical platform makes it easier to show this," says György Marko-Varga.

He believes it will be possible to use the new technology to develop safer and more effective drug candidates. In the future it could also be used in clinical treatment, to help doctors select the right drug for a specific patient.

The researchers first conducted animal experiments, using drug doses 100 times higher than those now measured in patients. The group then optimised and refined the technology to achieve the sensitivity needed for measuring doses of drugs normally administered to patients.


Story Source:

The above story is based on materials provided by Lund University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Thomas E. Fehniger, Ákos Végvári, Melinda Rezeli, Kaiu Prikk, Peeter Ross, Magnus Dahlbäck, Goutham Edula, Ruth Sepper, György Marko-Varga. Direct Demonstration of Tissue Uptake of an Inhaled Drug: Proof-of-Principle Study Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging. Analytical Chemistry, 2011; 111007105441003 DOI: 10.1021/ac2014349

Cite This Page:

Lund University. "Developing new drugs made easier with method to track drugs in tissue." ScienceDaily. ScienceDaily, 17 October 2011. <www.sciencedaily.com/releases/2011/10/111017102559.htm>.
Lund University. (2011, October 17). Developing new drugs made easier with method to track drugs in tissue. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2011/10/111017102559.htm
Lund University. "Developing new drugs made easier with method to track drugs in tissue." ScienceDaily. www.sciencedaily.com/releases/2011/10/111017102559.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) — Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) — Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) — Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) — Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins