Featured Research

from universities, journals, and other organizations

Significant weight gain in postmenopausal women increases risk for endometrial cancer, research suggests

Date:
October 24, 2011
Source:
American Association for Cancer Research
Summary:
Postmenopausal women who gained weight during adulthood had an increased risk for endometrial cancer compared with women who maintained a stable weight, according to new research.

Postmenopausal women who gained weight during adulthood had an increased risk for endometrial cancer compared with women who maintained a stable weight, according to data from the American Cancer Society's Cancer Prevention Study II Nutrition Cohort.

Related Articles


Victoria L. Stevens, Ph.D., strategic director of laboratory services at the National Home Office of the American Cancer Society in Atlanta, presented the data at the 10th AACR International Conference on Frontiers in Cancer Prevention Research, held Oct. 22-25, 2011.

Stevens and colleagues investigated whether adulthood weight gain and/or weight cycling, defined as the number of times a woman purposefully lost 10 pounds or more and then later regained the weight, increased the risk for endometrial cancer in postmenopausal women, independent of body mass index (BMI). Weight cycling, commonly referred to as "yo-yo" dieting, had previously been suggested to increase the amount of fat mass relative to lean body mass, according to Stevens.

"Fat tissue is the major source of circulating estrogen in postmenopausal women, and estrogen promotes the development of endometrial cancer," Stevens said. "Therefore, we hypothesized that weight cycling could be associated with risk for this cancer because women who engage in this behavior may have a higher proportion of fat than noncyclers."

The researchers collected data from 38,152 women with an intact uterus and who provided information on weight history and weight cycling on a 1992 questionnaire. Between 1992 and 2007, 560 women reported a diagnosis of endometrial cancer.

Overall, the results indicated that there was an almost fourfold increased risk for endometrial cancer in women who had gained 61 pounds or more in that timeframe, compared with women who maintained a stable weight. After adjustment for baseline BMI, the researchers found a twofold increased risk for endometrial cancer.

In addition, after adjustment, the researchers found no association between weight cycling, or yo-yo dieting, and endometrial cancer risk. "Weight gain during adulthood may increase risk for endometrial cancer in postmenopausal women, but weight cycling, which results from unsuccessful attempts to lose weight, does not increase risk for this cancer," Stevens said.

Future research should address whether the timing of weight gain and weight cycling during specific parts of adulthood, such as early adulthood versus middle age, influences the risk for endometrial cancer and whether weight loss decreases this risk, Stevens said.

"Weight gain during adulthood should be avoided to minimize risk for endometrial cancer," she said. "Women who have gained weight and are overweight or obese should continue to attempt to lose weight even though most weight loss will not be maintained."


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Significant weight gain in postmenopausal women increases risk for endometrial cancer, research suggests." ScienceDaily. ScienceDaily, 24 October 2011. <www.sciencedaily.com/releases/2011/10/111024084707.htm>.
American Association for Cancer Research. (2011, October 24). Significant weight gain in postmenopausal women increases risk for endometrial cancer, research suggests. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2011/10/111024084707.htm
American Association for Cancer Research. "Significant weight gain in postmenopausal women increases risk for endometrial cancer, research suggests." ScienceDaily. www.sciencedaily.com/releases/2011/10/111024084707.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins