Featured Research

from universities, journals, and other organizations

Some contraceptive pills more likely to cause blood clots, study confirms

Date:
October 26, 2011
Source:
BMJ-British Medical Journal
Summary:
A new study confirms previous findings that certain oral contraceptive pills are more likely to cause serious blood clots than others.

A study published online in the British Medical Journal confirms previous findings that certain oral contraceptive pills are more likely to cause serious blood clots (venous thromboembolism -- VTE ) than others.

The authors, led by Dr Ψjvind Lidegaard from the University of Copenhagen, say that women on pills containing one of the newer types of progestogen hormone (drospirenone, desogestrel or gestodene) have double the risk of VTE than women on pills containing an older progestogen (levonorgestrel).

Previous studies have indicated that the new types of progestogen hormone might increase the risk of VTE. So Lidegaard and colleagues carried out a large-scale study to assess the risk of VTE for women using oral contraceptives with different progestogens.

The researchers reviewed data of the hormonal contraception patterns and first time VTE episodes for all Danish non-pregnant women between the ages of 15 and 49 from January 2001 until December 2009.

The participants had no previous record of either blood clots or cancer before the study began.

The research team assessed over eight million women years of observation and during this period there were 4,246 first episodes of VTE.

The relative risk of VTE whilst taking the oral contraceptive pill is still low, explain the authors. Compared with non-users of hormonal contraception, pills with levonorgestrel increase the risk of VTE threefold and pills with drospirenone, desogestrel or gestodene increase the risk sixfold.

In absolute terms, the risk of VTE in current users of newer pills is about 10 per 10,000 women years. This means that about 2,000 women should shift from using oral contraceptives with desogestrel, gestodene, or drospirenone to those with levonorgestrel to prevent one event of VTE in one year, say the authors.

The increased risk remained even after taking account of other possible causes for VTE, they conclude.

In an accompanying editorial, Dr Philip Hannaford from the University of Aberdeen says "it is difficult not to conclude that combined oral contraceptives with desogestrel, gestodene or drospirenone confer a higher risk of venous thromboembolism than those with levonorgestrel" and that "many clinicians will choose to minimize the risk by prescribing a combined oral contraceptive with levonorgestrel whenever possible."

Hannaford stresses however that it is crucial "not to exaggerate the risk -- oral contraceptives are remarkably safe and may confer important long term benefits in relations to cancer and mortality."


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Journal References:

  1. O. Lidegaard, L. H. Nielsen, C. W. Skovlund, F. E. Skjeldestad, E. Lokkegaard. Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001-9. BMJ, 2011; 343 (oct25 4): d6423 DOI: 10.1136/bmj.d6423
  2. P. C. Hannaford. The progestogen content of combined oral contraceptives and venous thromboembolic risk. BMJ, 2011; 343 (oct25 1): d6592 DOI: 10.1136/bmj.d6592

Cite This Page:

BMJ-British Medical Journal. "Some contraceptive pills more likely to cause blood clots, study confirms." ScienceDaily. ScienceDaily, 26 October 2011. <www.sciencedaily.com/releases/2011/10/111025210915.htm>.
BMJ-British Medical Journal. (2011, October 26). Some contraceptive pills more likely to cause blood clots, study confirms. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2011/10/111025210915.htm
BMJ-British Medical Journal. "Some contraceptive pills more likely to cause blood clots, study confirms." ScienceDaily. www.sciencedaily.com/releases/2011/10/111025210915.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) — America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) — China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com
Hundreds in Virginia Turn out for a Free Clinic to Manage Health

Hundreds in Virginia Turn out for a Free Clinic to Manage Health

AFP (July 24, 2014) — America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th - prompting hundreds in Virginia to turn out for a free clinic run by “Remote Area Medical”. Duration 02:40 Video provided by AFP
Powered by NewsLook.com
Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) — An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins